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PMID: 6322122 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

The human c-Ha-ras2 is a processed pseudogene inactivated by numerous base substitutions.

Nucleic acids research ·Vol. 12 ·No. 4 ·1984-02-24 ·Pages 1821-8

Miyoshi J, Kagimoto M, Soeda E, Sakaki Y

Abstract

The human c-Ha-ras2 gene, one of two known members of the Harvey ras family, is reportedly located on the X-chromosome and has lost introns (1, 2). There has heretofore been no information on its precise gene structure and oncogenic potential. We have determined the nucleotide sequence of the c-Ha-ras2 and demonstrate that it is a processed pseudogene surrounded by several direct repeats and contains numerous base substitutions as well as a notable mutation (AGT at codon 12 of the p21 protein) responsible for oncogenic conversion of the known ras genes (3-8).

MeSH Terms
Base Composition Base Sequence Cell Transformation, Neoplastic Cloning, Molecular DNA Transposable Elements Female Genes, Viral Harvey murine sarcoma virus/genetics Humans Mutation Oncogenes Sarcoma Viruses, Murine/genetics X Chromosome/physiology
Chemicals
DNA Transposable Elements
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Miyoshi J
Kagimoto M
Soeda E
Sakaki Y
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38 references, click to expand
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Article Info
Journal
Nucleic acids research
Abbr.
Nucleic Acids Res
ISSN
0305-1048
DOI
10.1093/nar/12.4.1821
Published
1984-02-24
Pages
1821-8
Language
English
Region
England
NLM ID
0411011
PMCID
PMC318623
Subset
IM
Databases
GENBANK
X00419
External Links
PubMed source DOI: 10.1093/nar/12.4.1821 PMC Full Text View journal details
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