Structural and functional aspects of domain motions in proteins.

CRC critical reviews in biochemistry ·Vol. 15 ·No. 4 ·1984-00-00 ·Pages 291-384

Bennett WS, Huber R

Abstract

Three distinct categories of large-scale flexibility in proteins have been documented by single-crystal X-ray diffraction studies: the relatively free movement of essentially rigid globular domains that are connected by a flexible segment of polypeptide, the reorientation of essentially rigid domains among a few distinct conformations, and the concerted transition of a contiguous region of the surface of a protein from a disordered state to an ordered state. In a number of examples, well-defined functions can be assigned to these large-scale structural changes. The occurrence of such motions in proteins of known structure is reviewed, and the best-studied examples are discussed in detail to allow a critical evaluation of the methods used to identify and study these motions.

MeSH Terms

Alcohol Dehydrogenase Alcohol Oxidoreductases Amino Acyl-tRNA Synthetases Animals Aspartate Aminotransferases Capsid Proteins Carrier Proteins Citrate (si)-Synthase Complement Activating Enzymes Complement C1q DNA-Binding Proteins Disulfides Fibronectins Glucose/metabolism Glyceraldehyde-3-Phosphate Dehydrogenases Hexokinase Humans Immunoglobulin Fab Fragments Immunoglobulin Fc Fragments Immunoglobulin G Immunoglobulins Isoenzymes L-Lactate Dehydrogenase Laminin Myeloma Proteins Phosphotransferases Protease Inhibitors Protein Binding Protein Conformation Solutions Spectrin Staphylococcal Protein A Trypsin Inhibitors Trypsinogen Viral Proteins X-Ray Diffraction

Chemicals

Capsid Proteins Carrier Proteins DNA-Binding Proteins Disulfides Fibronectins H protein, Tobacco mosaic virus Immunoglobulin Fab Fragments Immunoglobulin Fc Fragments Immunoglobulin G Immunoglobulins Isoenzymes Laminin Myeloma Proteins Protease Inhibitors Solutions Staphylococcal Protein A Trypsin Inhibitors Viral Proteins immunoglobulin Kol Spectrin Complement C1q Trypsinogen Alcohol Oxidoreductases Alcohol Dehydrogenase L-Lactate Dehydrogenase Glyceraldehyde-3-Phosphate Dehydrogenases Citrate (si)-Synthase Aspartate Aminotransferases Phosphotransferases Hexokinase Complement Activating Enzymes Amino Acyl-tRNA Synthetases Glucose

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Bennett W S

Huber R

Article Info

Journal

CRC critical reviews in biochemistry

Abbr.

CRC Crit Rev Biochem

ISSN

0045-6411

DOI

10.3109/10409238409117796

Published

1984-00-00

Pages

291-384

Language

English

Region

United States

NLM ID

0330403

Subset

External Links

PubMed source DOI: 10.3109/10409238409117796

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Structural and functional aspects of domain motions in proteins.

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