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PMID: 6325591 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Differential effects of the enantiomers of 3-PPP on dopamine D1-receptors of isolated rabbit retina.

Journal of neural transmission ·Vol. 59 ·No. 1 ·1984-00-00 ·Pages 1-7

Schorderet M, Hjorth S, Hacksell U

Abstract

The effects of (+)- and (-)-3-PPP on cAMP levels of rabbit retina were investigated in vitro in the absence or presence of exogenous dopamine. In some experiments, a pre-incubation with reserpine was undertaken to deplete endogenous dopamine before the test. (+)- and (-)-3-PPP were found to be a weak dopamine-agonist and a weak dopamine-antagonist, respectively. Thus, the 3-PPP enantiomers may have opposite actions at the level of postsynaptic dopamine receptors, as previously suggested by studies in vivo.

MeSH Terms
Animals Cyclic AMP/metabolism Dopamine/pharmacology In Vitro Techniques Isomerism Piperidines/pharmacology Rabbits Receptors, Dopamine/drug effects Receptors, Dopamine D1 Retina/drug effects,metabolism
Chemicals
Piperidines Receptors, Dopamine Receptors, Dopamine D1 preclamol Cyclic AMP Dopamine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Schorderet M
Hjorth S
Hacksell U
References (10)
10 references, click to expand
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Article Info
Journal
Journal of neural transmission
Abbr.
J Neural Transm
DOI
10.1007/BF01249874
Published
1984-00-00
Pages
1-7
Language
English
Region
Austria
NLM ID
0337042
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01249874
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