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PMID: 6327762 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Immunopathogenetic roles of leukotrienes in human diseases.

Journal of clinical immunology ·Vol. 4 ·No. 2 ·1984-03-00 ·Pages 79-84

Goetzl EJ, Payan DG, Goldman DW

Abstract

The recent definition of the pathways of generation and structures of diverse products of the lipoxygenation of arachidonic acid has established the identity of a new family of mediators of hypersensitivity and inflammation. Studies of the effects of these mediators have shown that leukotrienes C, D, and E, the constitutents of the slow-reacting substance of anaphylaxis (SRS-A), are extremely potent smooth muscle contractile and vasoactive factors. Leukotriene B is a highly active stimulus of neutrophil and eosinophil functions and suppresses the immunological capabilities of T lymphocytes. The development of specific and sensitive radioimmunoassays has permitted the detection of elevated concentrations of leukotrienes in tissues or exudates in several diseases, including asthma, diverse allergic states, adult respiratory distress syndrome, psoriasis, spondyloarthritis, and gout. The application of selective inhibitors and antagonists of leukotrienes will clarify their pathogenetic contributions in human diseases and may yield new therapeutic approaches.

MeSH Terms
Arachidonate Lipoxygenases Arachidonic Acids/biosynthesis,metabolism,physiology Arthritis/metabolism Asthma/metabolism Cystic Fibrosis/metabolism Humans Hypersensitivity/metabolism Leukotriene A4 Leukotriene B4/biosynthesis,metabolism,physiology Leukotriene E4 Lipoxygenase/metabolism Psoriasis/metabolism SRS-A/analogs & derivatives,biosynthesis,metabolism,physiology Tears/analysis
Chemicals
Arachidonic Acids Leukotriene A4 SRS-A Leukotriene B4 Leukotriene E4 Arachidonate Lipoxygenases Lipoxygenase
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Goetzl E J
Payan D G
Goldman D W
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30 references, click to expand
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Article Info
Journal
Journal of clinical immunology
Abbr.
J Clin Immunol
ISSN
0271-9142
DOI
10.1007/BF00915039
Published
1984-03-00
Pages
79-84
Language
English
Region
Netherlands
NLM ID
8102137
Subset
IM
Grants
NIAID NIH HHS · AI 19784 · United States
NHLBI NIH HHS · HL 31809 · United States
External Links
PubMed source DOI: 10.1007/BF00915039 View journal details
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