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PMID: 6329949 Published · ppublish English Comparative Study Journal Article

A new determinant, Qa-m208, detected on T lymphocytes and transfected L cells by a Kb-specific monoclonal antibody.

Immunogenetics ·Vol. 19 ·No. 6 ·1984-00-00 ·Pages 461-74

Oudshoorn-Snoek M, Mellor AL, Flavell RA, Démant P

Abstract

A Kb-specific monoclonal antibody, 6.3.4, defining a new class I specificity, m208, reacts with some K and D region products and with a Qa determinant present on T lymphocytes but not detectable on thymocytes and B lymphocytes. The strain distribution of reactions indicates that this determinant is controlled by the Qa-Tla region, and shows no concordance with the strain distribution pattern of any of the known Qa antigens. The antibody reacts also with L cells expressing a cloned H-2b class I gene mapping in the Qa-Tla region.

MeSH Terms
Alleles Animals Antibodies, Monoclonal Antigens, Surface/analysis,genetics Base Sequence Cytotoxicity, Immunologic DNA Restriction Enzymes Histocompatibility Antigens/genetics Histocompatibility Antigens Class I Isoantibodies L Cells/immunology Major Histocompatibility Complex Mice Mice, Inbred Strains Species Specificity T-Lymphocytes/immunology Transfection
Chemicals
Antibodies, Monoclonal Antigens, Surface Histocompatibility Antigens Histocompatibility Antigens Class I Isoantibodies Q surface antigens DNA Restriction Enzymes
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Oudshoorn-Snoek M
Mellor A L
Flavell R A
Démant P
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40 references, click to expand
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Article Info
Journal
Immunogenetics
Abbr.
Immunogenetics
ISSN
0093-7711
DOI
10.1007/BF00403437
Published
1984-00-00
Pages
461-74
Language
English
Region
United States
NLM ID
0420404
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00403437 View journal details
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