Syngeneic monoclonal antiidiotype can induce cellular immunity to reovirus.
A syngeneic monoclonal antiidiotypic antibody was generated in BALB/c mice after repeated immunization with a BALB/c monoclonal anti-reovirus hemagglutinin (HA) antibody. The resultant syngeneic monoclonal antiidiotypic antibody, in the absence of adjuvant, was found to be capable of priming both BALB/c (H-2d, Igh-1a) and C3H/Hej (H-2k, Igh-1j) mice for Lyt-1+- and Lyt-2+-dependent responses against the mammalian reovirus. By the use of intertypic reassortants and variant virus analysis, the specificity of the response was finely mapped to the neutralization domain of the viral hemagglutinin (HA). Using purified monoclonal antiidiotype, we were able to compare the potency of antiidiotype to virus in terms of induction of immunity. 8 X 10(8) protein molecules were able to prime for cellular responses to reovirus. These studies indicate that in the reovirus system, T cells and B cells share idiotypic configurations, and that antiidiotypic antibodies of the type described herein may be useful in the development of vaccines against certain viral infections.
29 references, click to expand
-
Virus-receptor interaction in an adenovirus system.J Virol. 1968 Oct;2(10):1064-75 PMID: 5723709
-
Towards a network theory of the immune system.Ann Immunol (Paris). 1974 Jan;125C(1-2):373-89 PMID: 4142565
-
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.Anal Biochem. 1976 May 7;72:248-54 PMID: 942051
-
Genome RNAs and polypeptides of reovirus serotypes 1, 2, and 3.J Virol. 1977 Jun;22(3):726-33 PMID: 875135
-
Chemical structure of attachment sites for viruses on human erythrocytes.Nature. 1977 Aug 11;268(5620):536-7 PMID: 196216
-
Molecular basis of reovirus virulence: role of the S1 gene.Proc Natl Acad Sci U S A. 1977 Dec;74(12):5744-8 PMID: 271999
-
Mechanisms of regulation of cell-mediated immune responses. I. Effect of the route of immunization with TNP-coupled syngeneic cells on the induction and suppression of contact sensitivity to picryl chloride.J Immunol. 1978 May;120(5):1604-11 PMID: 659864
-
Generation of cytolytic T lymphocytes after reovirus infection: role of S1 gene.Proc Natl Acad Sci U S A. 1979 Jan;76(1):442-6 PMID: 218202
-
Interaction of reovirus with cell surface receptors. I. Murine and human lymphocytes have a receptor for the hemagglutinin of reovirus type 3.J Immunol. 1980 May;124(5):2143-8 PMID: 7365250
-
Delayed hypersensitivity in mice infected with reovirus. I. Identification of host and viral gene products responsible for the immune response.J Immunol. 1980 Jul;125(1):278-82 PMID: 6247395
-
Receptors for encephalomyocarditis virus on murine and human cells.Virology. 1980 Oct 30;106(2):261-72 PMID: 6254250
-
Induction of anti-H-2 antibodies without alloantigen exposure by in vivo administration of anti-idiotype.Nature. 1981 May 21;291(5812):233-5 PMID: 6785654
-
Protein sigma 1 is the reovirus cell attachment protein.Virology. 1981 Jan 15;108(1):156-63 PMID: 7269235
-
Implications of the presence of an internal image of the antigen in anti-idiotypic antibodies: possible application to vaccine production.Clin Immunol Immunopathol. 1981 Dec;21(3):397-406 PMID: 6173154
-
Viral receptors on isolated murine and human ependymal cells.Science. 1982 Jan 22;215(4531):419-21 PMID: 6276976
-
Evidence for functional domains on the reovirus type 3 hemagglutinin.Virology. 1982 Feb;117(1):146-55 PMID: 6175082
-
Host immune response to reovirus: CTL recognize the major neutralization domain of the viral hemagglutinin.J Immunol. 1982 Nov;129(5):2235-8 PMID: 6288802
-
Reovirus inhibition of cellular RNA and protein synthesis: role of the S4 gene.Virology. 1982 Oct 30;122(2):381-91 PMID: 6183822
-
Genetic studies on the mechanism of chemical and physical inactivation of reovirus.J Gen Virol. 1982 Nov;63 (Pt 1):149-59 PMID: 7175500
-
Monoclonal antibodies to the human insulin receptor block insulin binding and inhibit insulin action.Proc Natl Acad Sci U S A. 1982 Dec;79(23):7312-6 PMID: 6185950
-
Identification of idiotypic receptors on reovirus-specific cytolytic T cells.Proc Natl Acad Sci U S A. 1982 Dec;79(23):7479-83 PMID: 6984189
-
Hemagglutinin variants of reovirus type 3 have altered central nervous system tropism.Science. 1983 Apr 29;220(4596):505-7 PMID: 6301010
-
Topological analysis of the reovirus type 3 hemagglutinin.Virology. 1983 May;127(1):220-4 PMID: 6858002
-
Immune response to hepatitis B surface antigen: enhancement by prior injection of antibodies to the idiotype.Science. 1983 Aug 26;221(4613):853-5 PMID: 6603657
-
Cell receptors for the mammalian reovirus. I. Syngeneic monoclonal anti-idiotypic antibody identifies a cell surface receptor for reovirus.J Immunol. 1983 Nov;131(5):2533-8 PMID: 6313805
-
Cell receptors for the mammalian reovirus. II. Monoclonal anti-idiotypic antibody blocks viral binding to cells.J Immunol. 1983 Nov;131(5):2539-41 PMID: 6313806
-
Enhancement of the immune response to hepatitis B surface antigen. In vivo administration of antiidiotype induces anti-HBs that expresses a similar idiotype.J Exp Med. 1984 Mar 1;159(3):655-65 PMID: 6607967
-
Sendai virus-specific T cell clones. V. Induction of a virus-specific response by antiidiotypic antibodies directed against a T helper cell clone.J Exp Med. 1984 Jun 1;159(6):1778-83 PMID: 6327875
-
The mammalian cell-virus relationship. I. Attachment of poliovirus to cultivated cells of primate and non-primate origin.J Exp Med. 1959 May 1;109(5):475-85 PMID: 13641571
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: [email protected]
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
