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PMID: 6333356 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Inositol 1,4,5-trisphosphate may be a signal for f-Met-Leu-Phe-induced intracellular Ca mobilisation in human leucocytes (HL-60 cells).

FEBS letters ·Vol. 176 ·No. 1 ·1984-10-15 ·Pages 193-6

Burgess GM, McKinney JS, Irvine RF, Berridge MJ, Hoyle PC, Putney JW

Abstract

Permeabilised, dimethyl sulphoxide-differentiated HL-60 human myelomonocytic leukemia cells accumulate 45Ca in an ATP-dependent manner. The 45Ca is taken up by a pool thought to be a component of the endoplasmic reticulum. Inositol trisphosphate induced a rapid release of Ca from this pool, suggesting that this molecule which is formed in these cells in response to f-Met-Leu-Phe may play a role in agonist-induced Ca metabolism.

MeSH Terms
Adenosine Triphosphate/pharmacology Calcium/metabolism Cell Differentiation/drug effects Cell Line Cell Membrane Permeability Dimethyl Sulfoxide/pharmacology Humans Inositol 1,4,5-Trisphosphate Inositol Phosphates/pharmacology Leukemia, Myeloid N-Formylmethionine Leucyl-Phenylalanine/pharmacology Neutrophils/drug effects,metabolism Sugar Phosphates/pharmacology
Chemicals
Inositol Phosphates Sugar Phosphates N-Formylmethionine Leucyl-Phenylalanine Inositol 1,4,5-Trisphosphate Adenosine Triphosphate Calcium Dimethyl Sulfoxide
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Burgess G M
McKinney J S
Irvine R F
Berridge M J
Hoyle P C
Putney J W
Article Info
Journal
FEBS letters
Abbr.
FEBS Lett
ISSN
0014-5793
DOI
10.1016/0014-5793(84)80939-4
Published
1984-10-15
Pages
193-6
Language
English
Region
England
NLM ID
0155157
Subset
IM
Grants
NIDCR NIH HHS · DE-05764 · United States
External Links
PubMed source DOI: 10.1016/0014-5793(84)80939-4 View journal details
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