Home LiteratureArticle Details
PMID: 6334807 Published · ppublish English Journal Article

Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity.

Nature ·Vol. 312 ·No. 5996 ·1984-00-00 ·Pages 721-4

Gray PW, Aggarwal BB, Benton CV, Bringman TS, Henzel WJ, Jarrett JA, Leung DW, Moffat B, Ng P, Svedersky LP

Abstract

A chemically-synthesized gene and natural complementary DNA coding for human lymphotoxin were isolated and engineered for expression in Escherichia coli. Purified recombinant lymphotoxin shows cytotoxic activity on murine and human tumour cell lines in vitro and causes necrosis of certain murine sarcomas in vivo.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Cells, Cultured Cloning, Molecular DNA/genetics Gene Expression Regulation Humans Lymphokines/genetics Lymphotoxin-alpha/genetics,therapeutic use Mice Sarcoma, Experimental/therapy
Chemicals
Lymphokines Lymphotoxin-alpha DNA
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Gray P W
Aggarwal B B
Benton C V
Bringman T S
Henzel W J
Jarrett J A
Leung D W
Moffat B
Ng P
Svedersky L P
Article Info
Journal
Nature
Abbr.
Nature
ISSN
0028-0836
DOI
10.1038/312721a0
Published
1984-00-00
Pages
721-4
Language
English
Region
England
NLM ID
0410462
Subset
IM
Databases
GENBANK
X01393
External Links
PubMed source DOI: 10.1038/312721a0 View journal details
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