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PMID: 6337099 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Lipoteichoic acid is the major cell wall component responsible for surface hydrophobicity of group A streptococci.

Infection and immunity ·Vol. 39 ·No. 1 ·1983-01-00 ·Pages 336-43

Miörner H, Johansson G, Kronvall G

Abstract

The contribution of lipoteichoic acid (LTA) to the hydrophobic surface properties of group A streptococci was investigated in aqueous dextran-polyethylene glycol two-phase systems. Enzymatic digestions were performed to characterize the hydrophobic surface structure. The results obtained indicated that LTA is a major factor responsible for the hydrophobic character of the cell surface of group A streptococci. This was further supported by the similarity of partition in polymer two-phase systems between whole group A streptococci and tritiated LTA extracted from a group A streptococcal strain. Surface LTA was also determined on intact organisms by a new method measuring the adsorption of antibodies to LTA to the bacterial surface. A correlation was found between the content of surface LTA and the hydrophobicity of the group A streptococci. We conclude that surface-associated LTA is the major factor determining surface hydrophobicity of group A streptococci.

MeSH Terms
Antigens, Bacterial Bacterial Outer Membrane Proteins Bacterial Proteins/physiology Carrier Proteins Cell Wall/analysis Fatty Acids/pharmacology Hot Temperature Lipopolysaccharides Phagocytosis Phosphatidic Acids/analysis,physiology Polyethylene Glycols/pharmacology Solubility Streptococcus pyogenes/analysis Surface Properties Teichoic Acids/analysis,physiology
Chemicals
Antigens, Bacterial Bacterial Outer Membrane Proteins Bacterial Proteins Carrier Proteins Fatty Acids Lipopolysaccharides Phosphatidic Acids Teichoic Acids streptococcal M protein Polyethylene Glycols lipoteichoic acid
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Miörner H
Johansson G
Kronvall G
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37 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.39.1.336-343.1983
Published
1983-01-00
Pages
336-43
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC347944
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.39.1.336-343.1983 PMC Full Text View journal details
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