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PMID: 6348770 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Stimulation of mucosal mast cell growth in normal and nude rat bone marrow cultures.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 80 ·No. 14 ·1983-07-00 ·Pages 4499-503

Haig DM, McMenamin C, Gunneberg C, Woodbury R, Jarrett EE

Abstract

Mast cells with the morphological and biochemical properties of mucosal mast cells (MMC) appear and proliferate to form the predominant cell type in rat bone marrow cultures stimulated with factors from antigen- or mitogen-activated lymphocytes. Conditioned media causing a selective proliferation of MMC were derived from mesenteric lymph node cells of Nippostrongylus brasiliensis-infected rats restimulated in vitro with specific antigen or from normal or infected rat mesenteric lymph node cells stimulated with concanavalin A. MMC growth factor is not produced by T-cell-depleted mesenteric lymph node cells or by the mesenteric lymph node cells of athymic rats. By contrast, MMC precursors are present in the bone marrow of athymic rats and are normally receptive to the growth factor produced by the lymphocytes of thymus-intact rats. The thymus dependence of MMC hyperplasia is thus based on the requirement of a thymus-independent precursor for a T-cell-derived growth promoter.

MeSH Terms
Animals Bone Marrow/physiology Cell Division Cells, Cultured Intestinal Mucosa/physiology Intestine, Small/physiology Kinetics Lymph Nodes/immunology Lymphocytes/immunology Mast Cells/physiology Peptide Hydrolases/metabolism Rats Rats, Mutant Strains Thymus Gland/physiology
Chemicals
Peptide Hydrolases
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Haig D M
McMenamin C
Gunneberg C
Woodbury R
Jarrett E E
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24 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.80.14.4499
Published
1983-07-00
Pages
4499-503
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC384066
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.80.14.4499 PMC Full Text View journal details
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