Penicillin-binding proteins and the future of beta-lactam antibiotics. The Seventh Fleming Lecture.

Amino Acid Sequence Anti-Bacterial Agents/pharmacology Bacteria/drug effects Bacterial Proteins Carrier Proteins/metabolism Escherichia coli/enzymology Hexosyltransferases/metabolism Molecular Weight Multienzyme Complexes/metabolism Muramoylpentapeptide Carboxypeptidase Penicillin Resistance Penicillin-Binding Proteins Penicillins/metabolism Peptidyl Transferases/metabolism beta-Lactamases/metabolism beta-Lactams

Anti-Bacterial Agents Bacterial Proteins Carrier Proteins Multienzyme Complexes Penicillin-Binding Proteins Penicillins beta-Lactams Peptidyl Transferases Hexosyltransferases Muramoylpentapeptide Carboxypeptidase beta-Lactamases