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PMID: 6365236 Published · ppublish English Clinical Trial Comparative Study Journal Article Randomized Controlled Trial

Single dose treatment of vaginal candidosis: comparison of clotrimazole and isoconazole.

The British journal of venereal diseases ·Vol. 60 ·No. 1 ·1984-02-00 ·Pages 42-4

Cohen L

Abstract

The therapeutic efficacy of a single dose 500 mg tablet of clotrimazole was compared with two 300 mg tablets of isoconazole in an open randomised study of 100 patients with vaginal candidosis confirmed by mycological culture. One week after treatment 100% of the clotrimazole treated patients and 98% of the isoconazole treated group gave mycologically negative results. Five weeks after treatment these figures were 74% and 78% respectively, showing that both regimens were equally effective.

MeSH Terms

Adolescent Adult Candidiasis, Vulvovaginal/drug therapy Clinical Trials as Topic Clotrimazole/administration & dosage,therapeutic use Drug Administration Schedule Female Humans Imidazoles/administration & dosage Miconazole/administration & dosage,analogs & derivatives,therapeutic use Time Factors

Chemicals

Imidazoles Miconazole Clotrimazole isoconazole

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Cohen L

References (9)

9 references, click to expand

Relationship of Candida albicans in the genital and anorectal tracts.
Br J Vener Dis. 1966 Sep;42(3):197-200 PMID: 5919865
Six-day clotrimazole therapy in vaginal candidosis.
Curr Med Res Opin. 1975;3(2):83-8 PMID: 1095310
Three-day clotrimazole treatment in candidal vulvovaginitis.
Br J Vener Dis. 1977 Apr;53(2):126-8 PMID: 870143
Recurrent genital candidosis in women and the effect of intermittent prophylactic treatment.
Br J Vener Dis. 1978 Jun;54(3):176-83 PMID: 26452
Vaginal secretion levels after 6 days, 3 days and 1 day of treatment with 100, 200 and 500 mg vaginal tablets of clotrimazole and their therapeutic efficacy.
Chemotherapy. 1982;28 Suppl 1:43-7 PMID: 7160240
Effect of simultaneous oral and vaginal treatment on the rate of cure and relapse in vaginal candidosis.
Br J Vener Dis. 1979 Oct;55(5):362-5 PMID: 389354
Treatment off vulvovaginal candidal infection with miconazole-coated tampons.
Br J Vener Dis. 1980 Dec;56(6):408-11 PMID: 7470219
Treatment of vaginal candidosis with a single 500-mg clotrimazole pessary.
Br J Vener Dis. 1982 Apr;58(2):124-6 PMID: 7039762
Epidemiological investigation of patients with vulvovaginal candidosis. Application of a resistogram method for strain differentiation of Candida albicans.
Br J Vener Dis. 1979 Oct;55(5):357-61 PMID: 389353

Article Info

Journal

The British journal of venereal diseases

Abbr.

Br J Vener Dis

ISSN

0007-134X

DOI

10.1136/sti.60.1.42

Published

1984-02-00

Pages

42-4

Language

English

Region

England

NLM ID

0421042

PMCID

PMC1046268

Subset

External Links

PubMed source DOI: 10.1136/sti.60.1.42 PMC Full Text

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Single dose treatment of vaginal candidosis: comparison of clotrimazole and isoconazole.

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