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PMID: 6366521 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Chromosomal assignment of the murine gene encoding the transformation-related protein p53.

Molecular and cellular biology ·Vol. 4 ·No. 2 ·1984-02-00 ·Pages 383-5

Rotter V, Wolf D, Pravtcheva D, Ruddle FH

Abstract

p53 is a transformation-related protein that is encoded by the cellular genome and is synthesized at elevated levels in a wide range of different cell line types and in primary tumors of various species. By using several independently established anti-p53 monoclonal antibodies, it was possible to distinguish between p53 of mouse origin and p53 of Chinese hamster origin. By analysis of a series of mouse X Chinese hamster hybrid cell lines containing various mouse chromosomes, we mapped the p53 gene product to mouse chromosome 11.

MeSH Terms
Animals Antibodies, Monoclonal Chromosome Mapping Cricetinae Cricetulus Hybrid Cells Male Mice Mice, Inbred BALB C Phosphoproteins/genetics Species Specificity Transformation, Genetic Tumor Suppressor Protein p53
Chemicals
Antibodies, Monoclonal Phosphoproteins Tumor Suppressor Protein p53
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Rotter V
Wolf D
Pravtcheva D
Ruddle F H
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26 references, click to expand
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Article Info
Journal
Molecular and cellular biology
Abbr.
Mol Cell Biol
ISSN
0270-7306
DOI
10.1128/mcb.4.2.383-385.1984
Published
1984-02-00
Pages
383-5
Language
English
Region
United States
NLM ID
8109087
PMCID
PMC368708
Subset
IM
External Links
PubMed source DOI: 10.1128/mcb.4.2.383-385.1984 PMC Full Text View journal details
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