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PMID: 6370829 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Human oncogenes.

Human genetics ·Vol. 66 ·No. 2-3 ·1984-00-00 ·Pages 132-42

Willecke K, Schäfer R

Abstract

The information published on human oncogenes up to the fall of 1983 is reviewed. Retroviral oncogenes, proto-oncogenes, and cellular transforming genes are compared. Transforming genes derived from the ras gene family are described in detail. The different mechanisms of activation of proto-oncogenes are summarized. Finally, the concerted or sequential action of cellular transforming genes in the multi-step process of carcinogenesis is discussed.

MeSH Terms
Animals Carcinogens Cats Cebidae Cell Line Cell Transformation, Neoplastic Cell Transformation, Viral Chickens Gene Amplification Genes, Viral Humans Mice Mutation Neoplasms/genetics,microbiology Oncogenes Rats Retroviridae/genetics,growth & development Translocation, Genetic Tumor Virus Infections/genetics,microbiology Turkey Virus Activation
Chemicals
Carcinogens
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Willecke K
Schäfer R
References (86)
86 references, click to expand
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Article Info
Journal
Human genetics
Abbr.
Hum Genet
ISSN
0340-6717
DOI
10.1007/BF00286587
Published
1984-00-00
Pages
132-42
Language
English
Region
Germany
NLM ID
7613873
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00286587 View journal details
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