Distribution of B lymphocyte subsets in normal lymphoid tissue.

Clinical and experimental immunology ·Vol. 56 ·No. 2 ·1984-05-00 ·Pages 399-406

Murray LJ, Swerdlow SH, Habeshaw JA

Abstract

Using the ABC avidin-biotin peroxidase techniques and a series of monoclonal antibodies against B cell associated antigens, the anatomical distribution of B lymphocyte subsets was studied in reactive lymph node, tonsil and spleen. Evidence is presented for at least five major phenotypically distinct B cell subsets, each localized to specific compartments of peripheral lymphoid tissue. The possible relationship of these subsets of B lymphocytes to activation, maturation and function in the B cell lineage is discussed.

MeSH Terms

Antibodies, Monoclonal/immunology B-Lymphocytes/classification,immunology Humans Immunoenzyme Techniques Lymph Nodes/immunology Lymphoid Tissue/cytology,immunology Palatine Tonsil/immunology Spleen/immunology

Chemicals

Antibodies, Monoclonal

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Murray L J

Swerdlow S H

Habeshaw J A

References (27)

27 references, click to expand

Germinal centres and the origin of the B-cell system. I. Germinal centres in the rabbit appendix.
Immunology. 1974 Mar;26(3):497-507 PMID: 4546813
Immunologic characterization of human malignant lymphomas.
Cancer. 1974 Oct;34(4 Suppl):suppl:1488-503 PMID: 4608683
Immunologic approach to non-Hodgkin lymphomas and related leukemias. Analysis of the results of multiparameter studies of 425 cases.
Semin Hematol. 1978 Oct;15(4):322-51 PMID: 366759
Analysis of HLA-D region-associated molecules with monoclonal antibody.
Proc Natl Acad Sci U S A. 1979 Dec;76(12):6567-71 PMID: 392522
A monoclonal antibody to human acute lymphoblastic leukaemia antigen.
Nature. 1980 Feb 7;283(5747):583-5 PMID: 6928257
The differentiation and function of human T lymphocytes.
Cell. 1980 Apr;19(4):821-7 PMID: 6991122
Characterization of a human B lymphocyte-specific antigen.
J Immunol. 1980 Oct;125(4):1678-85 PMID: 6157744
A monoclonal antibody (BA-1) reactive with cells of human B lymphocyte lineage.
J Immunol. 1981 Jan;126(1):83-8 PMID: 6969748
Characterization of a human B cell-specific antigen (B2) distinct from B1.
J Immunol. 1981 May;126(5):1941-7 PMID: 6163824
Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures.
J Histochem Cytochem. 1981 Apr;29(4):577-80 PMID: 6166661
P-24: a human leukemia-associated and lymphohemopoietic progenitor cell surface structure identified with monoclonal antibody.
J Exp Med. 1981 Mar 1;153(3):726-31 PMID: 6788880
Identification with a monoclonal antibody of a predominantly B lymphocyte-specific determinant of the human leukocyte common antigen. Evidence for structural and possible functional diversity of the human leukocyte common molecule.
J Exp Med. 1981 Apr 1;153(4):753-65 PMID: 6166706
Expression of cell surface markers after human B lymphocyte activation.
Proc Natl Acad Sci U S A. 1981 Jun;78(6):3848-52 PMID: 6973760
The role of germinal centres in the generation of immunological memory.
Ciba Found Symp. 1981;84:265-80 PMID: 7023874
Stages of B cell differentiation in human lymphoid tissue.
J Exp Med. 1981 Sep 1;154(3):737-49 PMID: 7024458
Ubiquitous cell-surface glycoprotein on tumor cells is proliferation-associated receptor for transferrin.
Proc Natl Acad Sci U S A. 1981 Jul;78(7):4515-9 PMID: 6270680
Comparative expression of T9, T10, and Ia antigens on activated human T cell subsets.
Hum Immunol. 1981 Nov;3(3):247-59 PMID: 6458585
Infrequent normal B lymphocytes express features of B-chronic lymphocytic leukemia.
J Exp Med. 1982 Feb 1;155(2):623-8 PMID: 6977012
Biochemical characterisation of leukaemia-associated antigen p24 defined by the monoclonal antibody BA-2.
Biochim Biophys Acta. 1982 Mar 4;701(3):318-27 PMID: 6950791
CBA/N immune defective mice; evidence for the failure of a B cell subpopulation to be expressed.
Immunol Rev. 1982;64:117-36 PMID: 7044950
Germinal centre B cells: antigen specificity and changes in heavy chain class expression.
Nature. 1982 Jul 22;298(5872):377-9 PMID: 6806671
Two monoclonal antibodies (OKIa1 and OKT10) for the study of the final B cell maturation.
J Clin Immunol. 1982 Jul;2(3 Suppl):67S-74S PMID: 6813349
Surface phenotype of Peyer's patch germinal center cells: implications for the role of germinal centers in B cell differentiation.
J Immunol. 1982 Dec;129(6):2698-707 PMID: 6982940
The normal and malignant germinal centre.
Clin Haematol. 1982 Oct;11(3):531-59 PMID: 6756733
Antigens on human plasma cells identified by monoclonal antibodies.
J Immunol. 1983 Mar;130(3):1132-8 PMID: 6401780
Normal equivalent cells of B cell malignancies: analysis with monoclonal antibodies.
Br J Haematol. 1983 Jul;54(3):393-403 PMID: 6344913
AN AUTORADIOGRAPHIC STUDY OF THE GERMINAL CENTER IN SPLEEN WHITE PULP DURING EARLY INTERVALS OF THE IMMUNE RESPONSE.
Lab Invest. 1964 Feb;13:95-104 PMID: 14161668

Article Info

Journal

Clinical and experimental immunology

Abbr.

Clin Exp Immunol

ISSN

0009-9104

Published

1984-05-00

Pages

399-406

Language

English

Region

England

NLM ID

0057202

PMCID

PMC1536247

Subset

External Links

PubMed source PMC Full Text View journal details

Analysis Services

Distribution of B lymphocyte subsets in normal lymphoid tissue.

Contact

WeChat Official Account