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PMID: 6380552 Published · ppublish English Journal Article Review

The 1984 Walter Hubert lecture. Activation of transforming genes in neoplasms.

British journal of cancer ·Vol. 50 ·No. 2 ·1984-08-00 ·Pages 137-42

Cooper GM

Abstract

Cellular oncogenes have been identified by the biological activity of tumour DNAs in transfection assays and/or by homology to the transforming genes of retroviruses. In some tumours, the biological activity, organization or expression of these genes is altered, suggesting that such alterations contribute to the development of neoplastic disease. Experiments leading to the identification of cellular oncogenes are reviewed and our current understanding of the mechanisms by which they induce transformation of cells in culture and may contribute to the pathogenesis of neoplasms in vivo is discussed.

MeSH Terms
Animals B-Lymphocytes Burkitt Lymphoma/genetics Cell Line Cell Transformation, Neoplastic DNA, Neoplasm/genetics Humans Lymphoma/genetics Mice Neoplasms/etiology,genetics Neoplasms, Experimental/genetics Oncogenes Retroviridae/genetics Transcription, Genetic Transfection
Chemicals
DNA, Neoplasm
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Cooper G M
References (46)
46 references, click to expand
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Article Info
Journal
British journal of cancer
Abbr.
Br J Cancer
ISSN
0007-0920
DOI
10.1038/bjc.1984.155
Published
1984-08-00
Pages
137-42
Language
English
Region
England
NLM ID
0370635
PMCID
PMC1976883
Subset
IM
External Links
PubMed source DOI: 10.1038/bjc.1984.155 PMC Full Text View journal details
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