Abnormal binding of spectrin to the membrane of erythrocytes in some cases of hereditary spherocytosis.

Blut ·Vol. 36 ·No. 3 ·1978-03-15 ·Pages 145-8

Sheehy R, Ralston GB

Abstract

In two cases of hereditary spherocytosis that we have examined, spectrin was bound abnormally tightly to the erythrocyte membrane, and could not be released by low ionic strength dialysis. This type of behaviour occurs in normal red cells only after heating above 50 degrees C. It appears that some cases of spherocytosis may be due to the presence of a protein which is abnormally temperature sensitive.

MeSH Terms

Erythrocyte Membrane Erythrocytes Humans Membrane Proteins/metabolism Protein Binding Spectrin/metabolism Spherocytosis, Hereditary/blood Temperature

Chemicals

Membrane Proteins Spectrin

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Sheehy R

Ralston G B

References (5)

5 references, click to expand

Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane.
Biochemistry. 1971 Jun 22;10(13):2606-17 PMID: 4326772
A congenital haemolytic anaemia with thermal sensitivity of the erythrocyte membrane.
Br J Haematol. 1975 Apr;29(4):537-43 PMID: 1191563
The temperature-dependent dissociation of spectrin.
Biochim Biophys Acta. 1977 Mar 28;491(1):345-8 PMID: 849466
A quantitative study of the fragmentation and haemolysis of mammalian red cells by heat.
J Exp Biol. 1950 Sep;27(2):198-209 PMID: 14794855
Physical and chemical properties of a protein isolated from red cell membranes.
Biochemistry. 1970 Jan 6;9(1):50-7 PMID: 4983452

Article Info

Journal

Blut

Abbr.

Blut

ISSN

0006-5242

DOI

10.1007/BF00996653

Published

1978-03-15

Pages

145-8

Language

English

Region

Germany

NLM ID

0173401

Subset

External Links

PubMed source DOI: 10.1007/BF00996653

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Abnormal binding of spectrin to the membrane of erythrocytes in some cases of hereditary spherocytosis.

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