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PMID: 6384732 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Genetic studies on the beta subunit of Escherichia coli RNA polymerase. VI. A redundant region in the beta polypeptide.

Molecular & general genetics : MGG ·Vol. 196 ·No. 1 ·1984-00-00 ·Pages 64-7

Nene V, Glass RE

Abstract

A single species of RNA polymerase is responsible for the transcription of genetic material in Escherichia coli; and, each component of this essential enzyme is encoded by a single gene. Nevertheless, we report the characterisation of a viable deletion mutant lacking about 165 bp in the region coding for residues 965 to 1143 of the beta subunit of this enzyme. The foreshortened beta polypeptide appears to function as normal, suggesting that this region is, in fact, non-essential with regard to the usual functions of E. coli RNA polymerase.

MeSH Terms
Amino Acid Sequence DNA-Directed RNA Polymerases/genetics Escherichia coli/genetics Genes Genes, Bacterial Macromolecular Substances Mutation Structure-Activity Relationship
Chemicals
Macromolecular Substances DNA-Directed RNA Polymerases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Nene V
Glass R E
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24 references, click to expand
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Article Info
Journal
Molecular & general genetics : MGG
Abbr.
Mol Gen Genet
ISSN
0026-8925
DOI
10.1007/BF00334093
Published
1984-00-00
Pages
64-7
Language
English
Region
Germany
NLM ID
0125036
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00334093
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