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PMID: 6389362 Published · ppublish English Journal Article

Phenolic glycolipid 1 of Mycobacterium leprae causes nonspecific inflammation but has no effect on cell-mediated responses in mice.

Infection and immunity ·Vol. 46 ·No. 3 ·1984-12-00 ·Pages 802-8

Brett SJ, Lowe C, Payne SN, Draper P

Abstract

The involvement of the phenolic glycolipid from Mycobacterium leprae in cell-mediated immunity has been investigated in this study. The phenolic glycolipid itself does not appear to stimulate cell-mediated immunity directly, as shown by its failure to elicit a classical delayed-type hypersensitivity response in mice immunized with M. leprae or to stimulate M. leprae-immune lymph node cells in a lymphoproliferative assay. Intradermal vaccination with the phenolic glycolipid failed to influence the growth of M. leprae in mouse footpads. A nonspecific inflammatory response to the sonicated glycolipid was observed in mice vaccinated with whole M. leprae and in control animals. No evidence was obtained for any adjuvant or suppressive effect on cell-mediated immunity by the phenolic glycolipid either to M. leprae or an unrelated antigen (sheep erythrocytes); neither sensitization nor elicitation to either antigen was affected.

MeSH Terms
Adjuvants, Immunologic Animals Antigens, Bacterial/immunology Female Glycolipids/immunology Hypersensitivity, Delayed/immunology Immunity, Cellular Inflammation/microbiology Leprosy/immunology,prevention & control Lymph Nodes/immunology Mice Mice, Inbred CBA Mycobacterium leprae/growth & development,immunology Vaccination
Chemicals
Adjuvants, Immunologic Antigens, Bacterial Glycolipids
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Brett S J
Lowe C
Payne S N
Draper P
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25 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.46.3.802-808.1984
Published
1984-12-00
Pages
802-8
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC261616
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.46.3.802-808.1984 PMC Full Text View journal details
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