The effect of adrenaline on the electrogenic Na+ pump in cardiac muscle cells.

Experientia ·Vol. 34 ·No. 4 ·1978-04-15 ·Pages 488-90

Akasu T, Ohta Y, Koketsu K

Abstract

Electrogenic Na+ pump currents during K+-activated hyperpolarizations of bullfrog atrium muscle fibres are increased by adrenaline. The log dose-response relation between these currents and activating K+ concentrations is expressed by a sigmoidal curve, which is shifted in parallel to the left by adrenaline. It is suggested that adrenaline increases the rate of Na+ extrusion without increasing the Na/K coupling ratio and total number of pumping sites.

MeSH Terms

Animals Anura Epinephrine/pharmacology Membrane Potentials/drug effects Myocardium/metabolism Potassium/metabolism Sodium/metabolism

Chemicals

Sodium Potassium Epinephrine

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Akasu T

Ohta Y

Koketsu K

References (10)

10 references, click to expand

Activation of electrogenic Na+ pump by epinephrine in bullfrog atrium.
Jpn Heart J. 1977 Nov;18(6):860-6 PMID: 304908
The effect of adrenaline on the K+ -activated hyperpolarization of the sympathetic ganglion cell membrane in bullfrogs.
Jpn J Physiol. 1976;26(3):289-301 PMID: 1087356
Acceleration of the electrogenic Na+ pump by adrenaline in frog skeletal muscle fibres.
Life Sci. 1976 Oct 1;19(7):1009-13 PMID: 994707
Increase of labeled calcium uptake in heart muscle during potassium lack contracture.
J Gen Physiol. 1960 Jul;43:1193-206 PMID: 13838003
The effect of adrenaline on the tension developed in contractures and twitches of the ventricle of the frog.
J Physiol. 1968 Jul;197(2):479-509 PMID: 5716855
Analysis of slow inhibitory postsynaptic potential of bullfrog sympathetic ganglion.
J Neurophysiol. 1968 Sep;31(5):717-28 PMID: 4304051
Adrenaline and the electrogenic sodium pump in Rana catesbeiana sympathetic ganglion cells.
Experientia. 1976 Jan 15;32(1):57-9 PMID: 1082419
Voltage clamp experiments on ventricular myocarial fibres.
J Physiol. 1970 Mar;207(1):165-90 PMID: 5503866
[On the membrane effect of adrenalin on the myocardial fiber].
Pflugers Arch Gesamte Physiol Menschen Tiere. 1960;271:715-26 PMID: 13777928
[Effects of epinephrine on the resting potential of myocardial fibers of the auricle].
Experientia. 1956 Oct 15;12(10):396-8 PMID: 13375643

Article Info

Journal

Experientia

Abbr.

Experientia

ISSN

0014-4754

DOI

10.1007/BF01935944

Published

1978-04-15

Pages

488-90

Language

English

Region

Switzerland

NLM ID

0376547

Subset

External Links

PubMed source DOI: 10.1007/BF01935944

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The effect of adrenaline on the electrogenic Na+ pump in cardiac muscle cells.

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