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PMID: 6403137 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Low serum C4 concentrations: an inherited predisposition to insulin dependent diabetes?

British medical journal (Clinical research ed.) ·Vol. 286 ·No. 6369 ·1983-03-19 ·Pages 926-8

Vergani D, Johnston C, B-Abdullah N, Barnett AH

Abstract

Twenty two out of 86 insulin dependent diabetics had serum C4 concentrations below the normal range. None of 41 non-insulin dependent diabetics tested had low concentrations. Low C4 values were seen in insulin dependent diabetes irrespective of the duration of the disease and did not appear to correlate with complement activation. There was a close correlation in C4 values between identical cotwins, even when only one was diabetic. These results suggest that a low serum C4 concentration is an inherited phenomenon and may predispose towards the development of insulin dependent diabetes.

MeSH Terms

Adolescent Adult Aged Antigen-Antibody Complex/analysis Child Child, Preschool Complement Activation Complement C3/analysis Complement C3d Complement C4/analysis Diabetes Mellitus/drug therapy,genetics,immunology Diseases in Twins Female Humans Insulin/therapeutic use Male Middle Aged Pregnancy Twins, Monozygotic

Chemicals

Antigen-Antibody Complex Complement C3 Complement C4 Insulin Complement C3d

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Vergani D

Johnston C

B-Abdullah N

Barnett A H

References (13)

13 references, click to expand

In vivo studies in C4-deficient guinea pigs.
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Complement breakdown products in plasma from patients with systemic lupus erythematosus and patients with membranoproliferative or other glomerulonephritis.
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Detection of immune complexes in unheated sera by modified 125I-Clq binding test. Effect of heating on the binding of Clq by immune complexes and application of the test to systemic lupus erythematosus.
J Immunol. 1976 Jan;116(1):232-5 PMID: 1245740
Effect of selective complement deficiency on the rate of neutralization of enveloped viruses by human sera.
J Immunol. 1977 Jan;118(1):28-34 PMID: 187701
Islet-cell antibodies in diabetes mellitus.
Lancet. 1976 Dec 11;2(7998):1273-6 PMID: 63747
Two HLA-linked loci controlling the fourth component of human complement.
Proc Natl Acad Sci U S A. 1978 Oct;75(10):5165-9 PMID: 368809
Complement-fixing islet-cell antibodies in type-I diabetes: possible monitors of active beta-cell damage.
Lancet. 1980 Mar 29;1(8170):668-72 PMID: 6103089
Inherited structural polymorphism of the fourth component of human complement.
Proc Natl Acad Sci U S A. 1980 Jun;77(6):3576-80 PMID: 6932037
Cytotoxic autoantibodies to beta cells in the serum of patients with insulin-dependent diabetes mellitus.
N Engl J Med. 1980 Dec 25;303(26):1493-8 PMID: 7001237
Diabetes in identical twins. A study of 200 pairs.
Diabetologia. 1981 Feb;20(2):87-93 PMID: 7193616
On the significance of C2, C4, and factor B polymorphisms in disease.
Hum Genet. 1981;56(3):235-47 PMID: 7016719
C4: another marker for type I diabetes.
Lancet. 1982 Jan 2;1(8262):41 PMID: 6119428
HLA-A, B, C, DR antigens, Bf, C4 and glyoxalase I (GLO) polymorphisms in French Basques with insulin-dependent diabetes mellitus (IDDM).
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Article Info

Journal

British medical journal (Clinical research ed.)

Abbr.

Br Med J (Clin Res Ed)

ISSN

0267-0623

DOI

10.1136/bmj.286.6369.926

Published

1983-03-19

Pages

926-8

Language

English

Region

England

NLM ID

8302911

PMCID

PMC1547358

Subset

External Links

PubMed source DOI: 10.1136/bmj.286.6369.926 PMC Full Text

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