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PMID: 6404261 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Inhibition of histidine decarboxylase and tumour promoter-induced arachidonic acid release by lecanoric acid analogues.

Biochemical and biophysical research communications ·Vol. 110 ·No. 3 ·1983-02-10 ·Pages 733-9

Umezawa K, Muramatsu S, Ishizuka M, Sawa T, Takeuchi T, Matsushima T

Abstract

Lecanoric acid analogues containing benzanilide structure inhibited histidine decarboxylase and arachidonic acid release from the cell membrane phospholipids induced by a tumour promoter, 12-O-tetradecanoylphorbol-13-acetate. But they did not inhibit cellular binding of phorbol-12,13-dibutylate. Lecanoric acid analogues also inhibited prostaglandin synthetase and delayed-type hypersensitivity responses against sheep red blood cells in mice. Thus, lecanoric acid analogues antagonized several enzymic and cellular effects of the tumour promoter.

MeSH Terms
Animals Arachidonic Acid Arachidonic Acids/metabolism Benzamides/pharmacology Carboxy-Lyases/antagonists & inhibitors Cell Membrane/drug effects,metabolism Cells, Cultured Embryo, Mammalian Female Histidine Decarboxylase/antagonists & inhibitors Kinetics Membrane Lipids/metabolism Mice Phorbols/pharmacology Phospholipids/metabolism Pregnancy Rats Salicylates/pharmacology Structure-Activity Relationship Tetradecanoylphorbol Acetate/pharmacology
Chemicals
Arachidonic Acids Benzamides Membrane Lipids Phorbols Phospholipids Salicylates Arachidonic Acid lecanoric acid Carboxy-Lyases Histidine Decarboxylase Tetradecanoylphorbol Acetate
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Umezawa K
Muramatsu S
Ishizuka M
Sawa T
Takeuchi T
Matsushima T
Article Info
Journal
Biochemical and biophysical research communications
Abbr.
Biochem Biophys Res Commun
ISSN
0006-291X
DOI
10.1016/0006-291x(83)91022-7
Published
1983-02-10
Pages
733-9
Language
English
Region
United States
NLM ID
0372516
Subset
IM
External Links
PubMed source DOI: 10.1016/0006-291x(83)91022-7 View journal details
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