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PMID: 6407112 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Gamma interferon synthesis by human thymocytes and T lymphocytes inhibited by cyclosporin A.

Science (New York, N.Y.) ·Vol. 221 ·No. 4605 ·1983-07-01 ·Pages 63-5

Reem GH, Cook LA, Vilcek J

Abstract

Cyclosporin A depresses the synthesis of gamma interferon by human thymocytes and T lymphocytes in vitro. This observation is of potential clinical significance because the long-term treatment of transplant patients with cyclosporin A, a widely used immunosuppressive agent, can give rise to B-cell lymphoma resulting from Epstein-Barr virus activation.

MeSH Terms
Cell Division/drug effects Child, Preschool Cyclosporins/pharmacology Humans Infant Interferon-gamma/biosynthesis T-Lymphocytes/drug effects,metabolism Thymus Gland/cytology,drug effects,metabolism
Chemicals
Cyclosporins Interferon-gamma
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Reem G H
Cook L A
Vilcek J
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
DOI
10.1126/science.6407112
Published
1983-07-01
Pages
63-5
Language
English
Region
United States
NLM ID
0404511
Subset
IM
Grants
PHS HHS · A1-07055 · United States
PHS HHS · A1-12948 · United States
External Links
PubMed source DOI: 10.1126/science.6407112 View journal details
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