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PMID: 641151 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Selective induction of an immune response in human external secretions by ingestion of bacterial antigen.

The Journal of clinical investigation ·Vol. 61 ·No. 3 ·1978-03-00 ·Pages 731-7

Mestecky J, McGhee JR, Arnold RR, Michalek SM, Prince SJ, Babb JL

Abstract

Ingestion of capsules which contained killed Streptococcus mutans by four healthy human subjects led to the appearance of specific antibodies in external secretions. Salivary and lacrymal antibodies were detected within 1 wk of ingestion and continued to increase throughout a 14-day immunization period, with a gradual decline during the 2 ensuing months. A second period of immunization resulted in a pronounced increase of specific antibody levels which occurred earlier than in the primary immunization period and reached peak levels by day 10. No change was detected in serum antibody levels throughout either immunization period. The antibody activity in all secretions was associated with the immunoglobulin A class, as determined by immunochemical analyses. These data indicate that ingestion of bacterial antigens selectively stimulates the immune response in secretions.

MeSH Terms
Adult Agglutination Tests Antibody Formation Antigens, Bacterial/pharmacology Female Humans Immunity, Active Immunization Immunoglobulin A, Secretory/analysis Male Saliva/immunology Streptococcus mutans/immunology Tears/immunology Time Factors
Chemicals
Antigens, Bacterial Immunoglobulin A, Secretory
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Mestecky J
McGhee J R
Arnold R R
Michalek S M
Prince S J
Babb J L
References (35)
35 references, click to expand
  1. Protein measurement with the Folin phenol reagent.
    J Biol Chem. 1951 Nov;193(1):265-75 PMID: 14907713
  2. Origin and differentiation of lymphocytes involved in the secretory IgA responses.
    Cold Spring Harb Symp Quant Biol. 1977;41 Pt 1:201-15 PMID: 70311
  3. Mesenteric lymph node B lymphoblasts which home to the small intestine are precommitted to IgA synthesis.
    J Exp Med. 1977 Apr 1;145(4):866-75 PMID: 300777
  4. A plastic intraoral device for the collection of human parotid saliva.
    J Dent Res. 1977 Jul;56(7):728-33 PMID: 269151
  5. Formation of secretory and circulating antibodies after immunization with live and inactivated influenza virus vaccines.
    J Infect Dis. 1977 May;135(5):697-705 PMID: 858947
  6. Mucosal penetrability enhanced by serum-derived antibodies.
    Nature. 1977 Mar 17;266(5599):262-3 PMID: 846571
  7. Membrane cell markers in human leukemias and lymphomas.
    Ric Clin Lab. 1976 Apr-Jun;6(2):93-8 PMID: 1087994
  8. Naturally occurring secretory immunoglobulin A antibodies to Streptococcus mutans in human colostrum and saliva.
    Infect Immun. 1976 Aug;14(2):355-62 PMID: 971950
  9. The induction and characterization of secretory IgA antibodies.
    Adv Exp Med Biol. 1974;45(0):453-62 PMID: 4137981
  10. Origin, distribution and differentiation of IgA-producing cells.
    Adv Exp Med Biol. 1974;45(0):13-22 PMID: 4137873
  11. Proportion of human colostral immunoglobulin-A molecules containing the secretory determinant.
    Immunology. 1970 Feb;18(2):237-43 PMID: 4190418
  12. Implications of secretory immune system in viral infections.
    Adv Exp Med Biol. 1974;45(0):271-82 PMID: 4370090
  13. The role of the secretory immune system in protection against agents which infect the respiratory tract.
    Adv Exp Med Biol. 1974;45(0):283-94 PMID: 4370501
  14. Induction and properties of rabbit secretory A antibody directed to group A streptococcal carbohydrate.
    Immunochemistry. 1971 Dec;8(12):1137-55 PMID: 4113505
  15. Studies on human secretory immunoglobulin A. II. Subunit structure.
    J Immunol. 1972 Mar;108(3):738-47 PMID: 4110988
  16. Secretory gamma-A antibodies induced by local immunization.
    Nature. 1969 Feb 15;221(5181):679-81 PMID: 4180238
  17. The gut-associated lymphoid system: nature and properties of the large dividing cells.
    Eur J Immunol. 1974 Jun;4(6):435-43 PMID: 4213445
  18. Rubella immunization of volunteers via the respiratory tract.
    Infect Immun. 1973 Oct;8(4):497-502 PMID: 4200537
  19. Biochemical and serological properties of Streptococcus mutans from various human and animal sources.
    Acta Pathol Microbiol Scand B Microbiol Immunol. 1974 Jun;82(3):357-70 PMID: 4604154
  20. Secretory antibodies in milk of swine against transmissible gastroenteritis virus.
    Adv Exp Med Biol. 1974;45(0):337-42 PMID: 4607052
  21. Antibody response in the parotid fluid and serum of Irus monkeys (Macaca fascicularis) after local immunization with Streptococcus mutans.
    Infect Immun. 1975 Aug;12(2):281-92 PMID: 50286
  22. Evidence for a primary association between immunoblasts and small gut.
    Nature. 1972 Sep 15;239(5368):161-2 PMID: 4561962
  23. Pinocytosis by epithelium associated with lymphoid follicles in the bursa of Fabricius, appendix, and Peyer's patches. An electron microscopic study.
    Am J Anat. 1973 Apr;136(4):455-77 PMID: 4692973
  24. Peyer's patches: an enriched source of precursors for IgA-producing immunocytes in the rabbit.
    J Exp Med. 1971 Jul 1;134(1):188-200 PMID: 4934147
  25. Effective immunity to dental caries: protection of gnotobiotic rats by local immunization with Streptococcus mutans.
    J Immunol. 1975 Jan;114(1 Pt 2):300-5 PMID: 804000
  26. Repopulation with IgA-containing cells of bronchial and intestinal lamina propria after transfer of homologous Peyer's patch and bronchial lymphocytes.
    J Immunol. 1975 May;114(5):1599-604 PMID: 1091707
  27. A mechanism for the induction of immunological tolerance by antigen feeding: antigen-antibody complexes.
    J Exp Med. 1975 Dec 1;142(6):1509-19 PMID: 1104748
  28. Antibody-forming cells in human colostrum after oral immunisation.
    Nature. 1975 Oct 30;257(5529):797-8 PMID: 1102990
  29. Antibody production by human colostral cells. I. Immunoglobulin class, specificity, and quantity.
    Scand J Immunol. 1975 Sep;4(5-6):535-9 PMID: 1101370
  30. Local immunization in the mammary glands of the rabbit.
    J Immunol. 1976 May;116(5):1295-301 PMID: 774979
  31. Ingestion of Streptococcus mutans induces secretory immunoglobulin A and caries immunity.
    Science. 1976 Jun 18;192(4245):1238-40 PMID: 1273589
  32. Minor salivary glands as a major source of secretory immunoglobin A in the human oral cavity.
    Science. 1975 Dec 19;190(4220):1206-9 PMID: 1198107
  33. Purification and properties of dextransucrase from Streptococcus sanguis.
    Arch Oral Biol. 1969 May;14(5):469-78 PMID: 5255459
  34. The isolation and biologic activities of purified secretory IgA and IgG anti-Salmonella typhimurium "O" antibodies from rabbit intestinal fluid and colostrum.
    J Immunol. 1971 Jan;106(1):181-90 PMID: 5543709
  35. Homing of lymph-borne immunoblasts to the gut.
    Nature. 1970 Apr 18;226(5242):262-3 PMID: 5461810
Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI108986
Published
1978-03-00
Pages
731-7
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC372587
Subset
IM
External Links
PubMed source DOI: 10.1172/JCI108986 PMC Full Text View journal details
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