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PMID: 6414140 Published · ppublish English Comparative Study Journal Article

A comparative study of several agents alone and combined in protection of the rodent kidney from warm ischaemia: methylprednisolone, propranolol, furosemide, mannitol, and adenosine triphosphate-magnesium chloride.

Urological research ·Vol. 11 ·No. 3 ·1983-00-00 ·Pages 105-9

Aydin G, Okiye SE, Zincke H

Abstract

The effect of 60 min of in situ warm ischaemia (37 degrees C) on renal function was investigated in the rat model. In addition, the effect of pretreatment with intravenously administered furosemide, mannitol, propranolol, methylprednisolone, and adenosine triphosphate-magnesium chloride (ATP-MgCl2), singly or in combination, was studied. The ischaemic kidney was effectively protected by the administration of methylprednisolone alone but not by furosemide, mannitol, ATP-MgCl2, or propranolol singly or in combination. These results demonstrate that rat kidneys subjected to 60 min of warm ischaemia can be safely protected with methylprednisolone pretreatment (3 mg/100 g of body weight) 30 min before warm ischaemia.

MeSH Terms
Adenosine Triphosphate/therapeutic use Animals Blood Urea Nitrogen Creatinine/blood Female Furosemide/therapeutic use Ischemia/prevention & control Kidney/blood supply Kidney Transplantation Magnesium/therapeutic use Magnesium Chloride Mannitol/therapeutic use Methylprednisolone/therapeutic use Propranolol/therapeutic use Rats Rats, Inbred Strains
Chemicals
Magnesium Chloride Mannitol Furosemide Adenosine Triphosphate Propranolol Creatinine Magnesium Methylprednisolone
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Aydin G
Okiye S E
Zincke H
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23 references, click to expand
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Article Info
Journal
Urological research
Abbr.
Urol Res
ISSN
0300-5623
DOI
10.1007/BF00257713
Published
1983-00-00
Pages
105-9
Language
English
Region
Germany
NLM ID
0364311
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00257713 View journal details
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