Covalent attachment of soluble proteins by nonenzymatically glycosylated collagen. Role in the in situ formation of immune complexes.
The chronic tissue damage associated with long-term diabetes mellitus may arise in part from in situ immune complex formation by accumulated immunoglobulins and/or antigens bound to long-lived structural proteins that have undergone excessive nonenzymatic glycosylation. In this report, we have tested this hypothesis using nonenzymatically glycosylated collagen. Binding of both albumin and IgG averaged four times the amount bound to unmodified collagen. Both albumin and IgG (anti-BSA) bound to nonenzymatically glycosylated collagen retained their ability to form immune complexes in situ with free antibody and antigen.
20 references, click to expand
-
Chemistry of nonenzymic browning. II.Adv Food Res. 1965;14:167-283 PMID: 5341910
-
CHEMISTRY OF NONENZYMIC BROWNING. I. THE REACTION BETWEEN ALDOSES AND AMINES.Adv Food Res. 1963;12:1-52 PMID: 14280861
-
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.Anal Biochem. 1976 May 7;72:248-54 PMID: 942051
-
Immunopathology of renal extracellular membranes in diabetes mellitus. Specificity of tubular basement-membrane immunofluorescence.Diabetes. 1976 Aug;25(8):701-8 PMID: 782982
-
Studies of diabetic nephropathy in animals and man.Diabetes. 1976;25(2 SUPPL):850-7 PMID: 823065
-
Diabetic cataract formation: potential role of glycosylation of lens crystallins.Proc Natl Acad Sci U S A. 1978 Jun;75(6):2918-22 PMID: 275862
-
Experimental glomerulonephritis induced by in situ formation of immune complexes in glomerular capillary wall.Kidney Int. 1979 Aug;16(2):148-57 PMID: 390217
-
Glycosylated collagen.Biochem Biophys Res Commun. 1979 Nov 28;91(2):498-501 PMID: 518648
-
In situ immune complex formation and glomerular injury.Kidney Int. 1980 Jan;17(1):1-13 PMID: 6990087
-
Tetradecanoyl phorbol acetate stimulates latent collagenase production by cultured human endothelial cells.Cell. 1980 Jun;20(2):343-51 PMID: 6248239
-
In situ formation of subepithelial glomerular immune complexes in passive serum sickness.Kidney Int. 1980 May;17(5):631-7 PMID: 6447223
-
Increased glycosylation of glomerular basement membrane collagen in diabetes.Biochem Biophys Res Commun. 1980 Jul 31;95(2):765-9 PMID: 7417290
-
The biochemistry of the complications of diabetes mellitus.Annu Rev Biochem. 1981;50:385-432 PMID: 6168237
-
Increased concentration of albumin in kidney basement membranes in diabetes mellitus.Diabetes. 1981 Oct;30(10):843-6 PMID: 7274588
-
Nonenzymatic glycosylation of peripheral nerve protein in diabetes mellitus.Proc Natl Acad Sci U S A. 1981 Aug;78(8):5190-2 PMID: 6946466
-
Nonenzymatic glycosylation reduces the susceptibility of fibrin to degradation by plasmin.Diabetes. 1983 Jul;32(7):680-4 PMID: 6222931
-
Non-enzymatic glycosylation of tissue protein in diabetes in the rat.Diabetologia. 1983 May;24(5):377-81 PMID: 6873515
-
Polyantigenic expansion of basement membrane constituents in diabetic nephropathy.Diabetes. 1983 May;32 Suppl 2:34-9 PMID: 6400667
-
A modified ninhydrin reagent for the photometric determination of amino acids and related compounds.J Biol Chem. 1954 Dec;211(2):907-13 PMID: 13221596
-
The primary structure of collagen.Int Rev Connect Tissue Res. 1976;7:1-60 PMID: 177376
Contact
No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong
Qilu Normal University · Genelibs Bioinformatics Lab
750 Shunhua Rd, Jinan
2F, Bldg F, University Science Park
Tel: 0531-88819269
WeChat Official Account
Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.
Business Email
E-mail: [email protected]
Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2
