Effects of the anti-inflammatory serine esterase inhibitor, FOY, on phospholipase A2 (EC 3.1.1.4) activity in rabbit polymorphonuclear leukocytes.

Pharmacological research communications ·Vol. 15 ·No. 9 ·1983-10-00 ·Pages 869-78

Kunze H, Bohn E, Damerau B

Abstract

Phospholipase A2 activity of polymorphonuclear leukocytes (PMNLs) towards radioactively labelled phosphatidylethanolamine is inhibited by FOY (ethyl 4-(6-guanidinohexanoyloxy)-benzoate methanesulfonate) in concentrations above 10(-4)M. The inhibition is noncompetitive with respect to the substrate employed and depends on the pH. Impairment of PMNL phospholipase A2 activity could play a role in the anti-inflammatory effect of FOY: the release of fatty acids from membrane phospholipids is reduced and consequently also the biosynthesis of bioactive oxygenated arachidonate metabolites, among them inflammatory mediators.

MeSH Terms

Animals Esterases/antagonists & inhibitors Gabexate Glycogen/pharmacology Guanidines/pharmacology Hydrogen-Ion Concentration In Vitro Techniques Liver/enzymology Male Neutrophils/enzymology Phosphatidylethanolamines/metabolism Phospholipases/antagonists & inhibitors Phospholipases A/antagonists & inhibitors Phospholipases A2 Rabbits

Chemicals

Guanidines Phosphatidylethanolamines Gabexate Glycogen Esterases Phospholipases serine esterase Phospholipases A Phospholipases A2

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Kunze H

Bohn E

Damerau B

Article Info

Journal

Pharmacological research communications

Abbr.

Pharmacol Res Commun

ISSN

0031-6989

DOI

10.1016/s0031-6989(83)80094-0

Published

1983-10-00

Pages

869-78

Language

English

Region

United States

NLM ID

0236354

Subset

External Links

PubMed source DOI: 10.1016/s0031-6989(83)80094-0

Analysis Services

Effects of the anti-inflammatory serine esterase inhibitor, FOY, on phospholipase A2 (EC 3.1.1.4) activity in rabbit polymorphonuclear leukocytes.

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