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PMID: 6420985 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

DNA flow cytometric measurements in inflammatory and malignant human gastric lesions.

Virchows Archiv. A, Pathological anatomy and histopathology ·Vol. 402 ·No. 2 ·1983-00-00 ·Pages 185-93

Deinlein E, Schmidt H, Riemann JF, Grässel-Pietrusky R, Hornstein OP

Abstract

102 gastroscopically taken biopsy specimens which were normal (n = 28) or showed superficial gastritis (n = 18), chronic atrophic gastritis (n = 18), gastric ulcers (n = 19) and gastric carcinomas (n = 19) were submitted to FCM analysis. Carcinomatous specimens were readily recognized by either ploidy abnormality or significantly raised S- and G2 + M values. Intestinal-type and diffuse carcinomas could not be distinguished by proliferation kinetics, however, diffuse carcinomas showed a higher rate of aneuploidy. Chronic atrophic gastritis and gastric ulcers, though significantly differing from both normal tissue and superficial gastritis, exhibited similar proliferation characteristics. In gastric ulcers, an S-phase proportion of more than 12% was correlated with histological detection of cellular atypias and a proliferative tendency.

MeSH Terms
Adult Aged Aneuploidy Biopsy DNA/analysis DNA, Neoplasm/analysis Diagnosis, Differential Female Flow Cytometry Gastritis/pathology Humans Male Middle Aged Stomach Neoplasms/pathology Stomach Ulcer/pathology
Chemicals
DNA, Neoplasm DNA
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Deinlein E
Schmidt H
Riemann J F
Grässel-Pietrusky R
Hornstein O P
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28 references, click to expand
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Article Info
Journal
Virchows Archiv. A, Pathological anatomy and histopathology
Abbr.
Virchows Arch A Pathol Anat Histopathol
ISSN
0174-7398
DOI
10.1007/BF00695060
Published
1983-00-00
Pages
185-93
Language
English
Region
Germany
NLM ID
8302198
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00695060
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