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PMID: 6421742 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Monoclonal antibody that recognizes an outer membrane antigen common to the pathogenic Neisseria species but not to most nonpathogenic Neisseria species.

Infection and immunity ·Vol. 43 ·No. 3 ·1984-03-00 ·Pages 994-9

Cannon JG, Black WJ, Nachamkin I, Stewart PW

Abstract

A hybridoma derived from a mouse immunized with gonococcal outer membranes produced an antibody, designated H.8, that bound to all strains of Neisseria gonorrhoeae and N. meningitidis tested, and to N. lactamica and N. cinerea, but only rarely to other nonpathogenic Neisseria species. Studies with the gonococcal strain used in production of the antibody showed that the antibody bound to a surface-exposed, protease-sensitive, and heat-modifiable outer membrane antigen that we believe is distinct from previously described gonococcal outer membrane proteins.

MeSH Terms
Animals Antibodies, Bacterial/biosynthesis,immunology,physiology Antibodies, Monoclonal/biosynthesis,immunology,physiology Antigens, Bacterial/analysis,immunology Bacterial Outer Membrane Proteins Binding Sites, Antibody Membrane Proteins/analysis,immunology,metabolism Mice Mice, Inbred BALB C Neisseria/immunology,pathogenicity Neisseria gonorrhoeae/immunology Neisseria meningitidis/immunology
Chemicals
Antibodies, Bacterial Antibodies, Monoclonal Antigens, Bacterial Bacterial Outer Membrane Proteins Membrane Proteins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Cannon J G
Black W J
Nachamkin I
Stewart P W
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30 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.43.3.994-999.1984
Published
1984-03-00
Pages
994-9
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC264283
Subset
IM
Grants
NIAID NIH HHS · AI15036 · United States
External Links
PubMed source DOI: 10.1128/iai.43.3.994-999.1984 PMC Full Text View journal details
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