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PMID: 6424126 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Neuronal growth cones: specific interactions mediated by filopodial insertion and induction of coated vesicles.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 81 ·No. 6 ·1984-03-00 ·Pages 1849-53

Bastiani MJ, Goodman CS

Abstract

We are interested in the factors that guide individual neuronal growth cones during embryonic development. Here we report on the discovery of a highly specific interaction between developing growth cones in the grasshopper embryo as revealed by transmission electron microscope serial-section reconstructions. Numerous filopodia from an identified growth cone (MP1) insert deep within another identified growth cone (pCC), inducing the formation of coated pits and vesicles. This interaction is highly specific, since filopodia from other nearby growth cones that contact the surface of the two interacting neurons neither penetrate them nor induce coated vesicles. These specific filopodial interactions may play an important role in the subsequent development of these neurons.

MeSH Terms
Animals Cell Membrane/ultrastructure Coated Pits, Cell-Membrane/physiology Cytoplasmic Granules/physiology Grasshoppers/embryology Intracellular Membranes/ultrastructure Microscopy, Electron Neurons/physiology,ultrastructure
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Bastiani M J
Goodman C S
References (13)
13 references, click to expand
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.81.6.1849
Published
1984-03-00
Pages
1849-53
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC345019
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.81.6.1849 PMC Full Text View journal details
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