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PMID: 6426382 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Resistance of Pseudomonas aeruginosa mutants with altered control of chromosomal beta-lactamase to piperacillin, ceftazidime, and cefsulodin.

Antimicrobial agents and chemotherapy ·Vol. 25 ·No. 3 ·1984-03-00 ·Pages 382-4

Bryan LE, Kwan S, Godfrey AJ

Abstract

Examination of beta-lactam susceptibility of mutants altered in the control of chromosomal beta-lactamase of Pseudomonas aeruginosa supports the view that a constitutive level of beta-lactamase is not an adequate explanation for resistance to cefsulodin and ceftazidime but could be for resistance to piperacillin which has an efficiency of hydrolysis ca. 10 times higher than does cefsulodin or ceftazidime.

MeSH Terms
Anti-Bacterial Agents/pharmacology Cefsulodin Ceftazidime Cephalosporins/pharmacology Chromosomes, Bacterial/enzymology Kinetics Microbial Sensitivity Tests Mutation Penicillin Resistance Piperacillin/pharmacology Pseudomonas aeruginosa/drug effects,genetics beta-Lactamases/metabolism
Chemicals
Anti-Bacterial Agents Cephalosporins Ceftazidime beta-Lactamases Cefsulodin Piperacillin
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Bryan L E
Kwan S
Godfrey A J
References (11)
11 references, click to expand
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    Antimicrob Agents Chemother. 1983 Jan;23(1):91-7 PMID: 6402977
  2. Morphological heterogeneity among Salmonella lipopolysaccharide chemotypes in silver-stained polyacrylamide gels.
    J Bacteriol. 1983 Apr;154(1):269-77 PMID: 6187729
  3. Novel resistance selected by the new expanded-spectrum cephalosporins: a concern.
    J Infect Dis. 1983 Mar;147(3):585-9 PMID: 6601169
  4. Chromosomal beta-lactamases of Enterobacter cloacae are responsible for resistance to third-generation cephalosporins.
    Antimicrob Agents Chemother. 1983 Jun;23(6):918-25 PMID: 6351733
  5. Beta-lactamase assays.
    Methods Enzymol. 1975;43:69-85 PMID: 237219
  6. Trapping of nonhydrolyzable cephalosporins by cephalosporinases in Enterobacter cloacae and Pseudomonas aeruginosa as a possible resistance mechanism.
    Antimicrob Agents Chemother. 1982 May;21(5):711-7 PMID: 6808912
  7. Properties of the penicillin-binding proteins of Escherichia coli K12,.
    Eur J Biochem. 1977 Jan;72(2):341-52 PMID: 319999
  8. beta-Lactam-resistant Pseudomonas aeruginosa with modified penicillin-binding proteins emerging during cystic fibrosis treatment.
    Antimicrob Agents Chemother. 1981 May;19(5):705-11 PMID: 6457554
  9. Mutational enzymatic resistance of Enterobacter species to beta-lactam antibiotics.
    Antimicrob Agents Chemother. 1982 Apr;21(4):655-60 PMID: 6979311
  10. Resistance to cefamandole: derepression of beta-lactamases by cefoxitin and mutation in Enterobacter cloacae.
    J Infect Dis. 1982 Jul;146(1):34-42 PMID: 6979593
  11. The use of analytical isoelectric focusing for detection and identification of beta-lactamases.
    J Gen Microbiol. 1975 May;88(1):169-78 PMID: 807678
Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.25.3.382
Published
1984-03-00
Pages
382-4
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC185525
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.25.3.382 PMC Full Text View journal details
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