Hyaluronic acid enhances phagocytosis of human monocytes in vitro.

Journal of clinical immunology ·Vol. 4 ·No. 3 ·1984-05-00 ·Pages 246-9

Ahlgren T, Jarstrand C

Abstract

Pretreatment of human blood monocytes with hyaluronic acid for 0.5 hr enhanced significantly their ingestion in vitro of yeast particles opsonized with complement. The enhancement of the phagocytic capacity was dose dependent and maximal in the range of 25-50 micrograms/ml.

MeSH Terms

Cell Adhesion/drug effects Chondroitin Sulfates/pharmacology Dose-Response Relationship, Drug Humans Hyaluronic Acid/pharmacology Monocytes/drug effects,immunology Opsonin Proteins/pharmacology Phagocytosis/drug effects Yeasts/immunology

Chemicals

Opsonin Proteins Hyaluronic Acid Chondroitin Sulfates

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Ahlgren T

Jarstrand C

References (7)

7 references, click to expand

Binding of hyaluronate to the surface of cultured cells.
J Cell Biol. 1979 Aug;82(2):475-84 PMID: 479311
Inhibition of leukocyte locomotion by hyaluronic acid.
J Cell Sci. 1981 Apr;48:315-31 PMID: 7276093
Inhibition of phagocytosis by high molecular weight hyaluronate.
Immunology. 1980 Jul;40(3):435-46 PMID: 7429537
The isolation and selected properties of blood monocytes.
J Exp Med. 1966 Jan 1;123(1):145-60 PMID: 4285446
Regulation of granulocyte function by hyaluronic acid. In vitro and in vivo effects on phagocytosis, locomotion, and metabolism.
J Clin Invest. 1980 Aug;66(2):298-305 PMID: 7400316
Molecular weight-dependent distribution of acidic glycosaminoglycans in human plasma.
Clin Chim Acta. 1977 Feb 15;75(1):59-69 PMID: 844202
Physicochemical surface changes on phagocytic cells during differentiation in relation to chemotaxis and phagocytosis.
Adv Exp Med Biol. 1982;141:531-7 PMID: 7090925

Article Info

Journal

Journal of clinical immunology

Abbr.

J Clin Immunol

ISSN

0271-9142

DOI

10.1007/BF00914973

Published

1984-05-00

Pages

246-9

Language

English

Region

Netherlands

NLM ID

8102137

Subset

External Links

PubMed source DOI: 10.1007/BF00914973 View journal details

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Hyaluronic acid enhances phagocytosis of human monocytes in vitro.

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