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LiteratureArticle Details
PMID: 643068
Published · ppublish
English
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.
Mechanism of resistance to thiostrepton in the producing-organism Streptomyces azureus.
Abstract
An antibiotic-producing organism, Streptomyces azureus, defends itself against its own toxic product by methylating the RNA of its ribosomes.
MeSH Terms
Anti-Bacterial Agents/pharmacology
Binding Sites
Drug Resistance, Microbial
Guanine Nucleotides/metabolism
Methyltransferases/metabolism
Peptide Elongation Factors
RNA, Ribosomal/metabolism
Ribosomes/drug effects,metabolism
Streptomyces/drug effects
Thiostrepton/metabolism,pharmacology
Chemicals
Anti-Bacterial Agents
Guanine Nucleotides
Peptide Elongation Factors
RNA, Ribosomal
Methyltransferases
Thiostrepton
Article Info
Journal
Nature
Abbr.
Nature
ISSN
0028-0836
Published
1978-04-27
Pages
792-5
Language
English
Region
England
NLM ID
0410462
Subset
IM
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