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PMID: 6432634 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Early organogenesis of human small intestine: scanning electron microscopy and brush border enzymology.

Gut ·Vol. 25 ·No. 9 ·1984-09-00 ·Pages 925-30

Lacroix B, Kedinger M, Simon-Assmann P, Haffen K

Abstract

Human small bowel early organogenesis was studied by scanning electron microscopy and found to be correlated to brush border enzymology. The appearance of the brush border enzymes sucrase, lactase, and aminopeptidase (measured in a purified apical membrane fraction) coincides with the first outgrowth of villi (eight weeks). Alkaline phosphatase was detected at seven weeks. The content of these enzymes furthermore increased up to the 14th week when both sucrase and aminopeptidase activities were comparable with adult values.

MeSH Terms
Alkaline Phosphatase/metabolism Aminopeptidases/metabolism Gestational Age Humans Intestinal Mucosa/ultrastructure Intestine, Small/embryology,enzymology,ultrastructure Microscopy, Electron, Scanning Microvilli/enzymology Sucrase/metabolism beta-Galactosidase/metabolism
Chemicals
Alkaline Phosphatase beta-Galactosidase Sucrase Aminopeptidases
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Lacroix B
Kedinger M
Simon-Assmann P
Haffen K
References (35)
35 references, click to expand
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Article Info
Journal
Gut
Abbr.
Gut
ISSN
0017-5749
DOI
10.1136/gut.25.9.925
Published
1984-09-00
Pages
925-30
Language
English
Region
England
NLM ID
2985108R
PMCID
PMC1432492
Subset
IM
External Links
PubMed source DOI: 10.1136/gut.25.9.925 PMC Full Text View journal details
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