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PMID: 6435246 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Chromosomal location of human T-cell receptor gene Ti beta.

Science (New York, N.Y.) ·Vol. 226 ·No. 4672 ·1984-10-19 ·Pages 348-9

Barker PE, Ruddle FH, Royer HD, Acuto O, Reinherz EL

Abstract

A complementary DNA probe corresponding to the beta-chain gene of Ti, the human T lymphocyte receptor, has been molecularly cloned. The chromosomal origin of the Ti beta gene was determined with the complementary DNA by screening a series of 12 cell hybrid (mouse X human) DNA's containing overlapping subsets of human chromosomes. DNA hybridization (Southern) experiments showed that the human Ti beta gene resides on chromosome 7 and is thus not linked to the immunoglobulin loci or to the major histocompatibility locus in humans.

MeSH Terms

Animals Chromosome Mapping Chromosomes, Human, 6-12 and X Cloning, Molecular DNA Genes Genetic Linkage Humans Hybrid Cells Immunoglobulin kappa-Chains/genetics Major Histocompatibility Complex Mice Nucleic Acid Hybridization Receptors, Antigen, T-Cell/genetics

Chemicals

Immunoglobulin kappa-Chains Receptors, Antigen, T-Cell DNA

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Barker P E

Ruddle F H

Royer H D

Acuto O

Reinherz E L

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.6435246

Published

1984-10-19

Pages

348-9

Language

English

Region

United States

NLM ID

0404511

Subset

Grants

NIAID NIH HHS · AI 21226 · United States

NIGMS NIH HHS · GM-09966 · United States

NIAID NIH HHS · R0 1 AI 19807 · United States

External Links

PubMed source DOI: 10.1126/science.6435246 View journal details

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Chromosomal location of human T-cell receptor gene Ti beta.

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