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PMID: 6438528 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Molecular cloning of a cDNA encoding human antihaemophilic factor.

Nature ·Vol. 312 ·No. 5992 ·1984-00-00 ·Pages 342-7

Toole JJ, Knopf JL, Wozney JM, Sultzman LA, Buecker JL, Pittman DD, Kaufman RJ, Brown E, Shoemaker C, Orr EC

Abstract

A complete copy of the mRNA sequences encoding human coagulation factor VIII:C has been cloned and expressed. The DNA sequence predicts a single chain precursor of 2,351 amino acids with a relative molecular mass (Mr) 267,039. The protein has an obvious domain structure, contains sequence repeats and is structurally related to factor V and ceruloplasmin.

MeSH Terms
Animals Antigens/genetics Cloning, Molecular DNA/genetics Factor VIII/genetics,immunology Gene Expression Regulation Genes Humans Molecular Weight RNA, Messenger/genetics Swine
Chemicals
Antigens RNA, Messenger Factor VIII DNA
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Toole J J
Knopf J L
Wozney J M
Sultzman L A
Buecker J L
Pittman D D
Kaufman R J
Brown E
Shoemaker C
Orr E C
Article Info
Journal
Nature
Abbr.
Nature
ISSN
0028-0836
DOI
10.1038/312342a0
Published
1984-00-00
Pages
342-7
Language
English
Region
England
NLM ID
0410462
Subset
IM
Grants
NHLBI NIH HHS · HL-17430 · United States
Databases
GENBANK
K01740
External Links
PubMed source DOI: 10.1038/312342a0 View journal details
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