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PMID: 6444942 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Suppression of induction of SOS functions in an Escherichia coli tif-1 mutant by plasmid R100.1.

Journal of bacteriology ·Vol. 141 ·No. 2 ·1980-02-00 ·Pages 464-9

Bagdasarian M, D'Ari R, Filipowicz W, George J

Abstract

The tif-1 mutation in the recA gene of Escherichia coli caused, at 40 degrees C, lethal cell filamentation, induction of the recA protein, mutagenesis, and, in lambda lysogens, prophage induction. The presence of plasmid R100.1 in tif-1 strains suppressed tif-mediated cell filamentation and killing, recA protein induction, and prophage induction in lysogens. It also reduced mutagenesis in a tif-1 sfiA11(R100.1) strain. Plasmids F'lac, P1, and pMB9, in contrast, had little or no effect on tif-mediated induction of lambda. The presence of R100.1 did not inhibit the induction of the recA protein or of lambda by ultraviolet irradiation or mitomycin C treatment of tif-1(R100.1) or tif-1(lambda)(R100.1) strains.

MeSH Terms
Adenine/metabolism Bacteriophage lambda/growth & development DNA Repair Escherichia coli/genetics,metabolism Mutation R Factors Temperature Viral Proteins/biosynthesis Virus Activation
Chemicals
Viral Proteins Adenine
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Bagdasarian M
D'Ari R
Filipowicz W
George J
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41 references, click to expand
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.141.2.464-469.1980
Published
1980-02-00
Pages
464-9
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC293648
Subset
IM
External Links
PubMed source DOI: 10.1128/jb.141.2.464-469.1980 PMC Full Text View journal details
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