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PMID: 64459 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Cellular origin of interferon induced by bacterial lipopolysaccharide.

Infection and immunity ·Vol. 15 ·No. 1 ·1977-01-00 ·Pages 78-83

Maehara N, Ho M

Abstract

Bacterial lipopolysaccharide (LPS) induces interferons with different properties in mouse macrophages and B lymphocytes. Macrophage interferon is labile at 56 degrees C and is neutralized by anti-mouse fibroblast interferon at a dilution of 1:6,142. B cell interferon is more heat stable and is neutralized by the same antiserum only at a dilution of 1:276. Serum obtained early (1 h) after an intravenous injection of 100 mug of LPS resembled macrophage interferon, whereas serum obtained at later times resembled more and more B cell interferon. The diverse cellular origin of LPS-induced interferon may explain the broad hyporesponsiveness produced by LPS in animals.

MeSH Terms
Animals Antibodies/analysis Antilymphocyte Serum/pharmacology B-Lymphocytes/immunology Epitopes Escherichia coli/immunology Female Hot Temperature Hydrogen-Ion Concentration Interferon Inducers Interferons/biosynthesis Lipopolysaccharides/pharmacology Macrophages/immunology Male Mice Mice, Inbred Strains Polysaccharides, Bacterial/pharmacology Spleen/cytology T-Lymphocytes/immunology
Chemicals
Antibodies Antilymphocyte Serum Epitopes Interferon Inducers Lipopolysaccharides Polysaccharides, Bacterial Interferons
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Maehara N
Ho M
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20 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.15.1.78-83.1977
Published
1977-01-00
Pages
78-83
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC421331
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.15.1.78-83.1977 PMC Full Text View journal details
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