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PMID: 6446408 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

EGF growth promoting activity is neutralized by phorbol esters.

Cell biology international reports ·Vol. 4 ·No. 1 ·1980-01-00 ·Pages 23-8

Lechner JF, Kaighn ME

Abstract

The tumor-promoter, TPA, stimulates growth of human epithelial cells but not that of normal fibroblasts. In the presence of either EGF or FGF, TPA antagonizes the growth stimulatory activity of both factors in both cell lines.

MeSH Terms
Cell Division/drug effects Cells, Cultured Epidermal Growth Factor/antagonists & inhibitors Fibroblast Growth Factors Fibroblasts Growth Inhibitors Humans Insulin/pharmacology Mitogens/pharmacology Peptides/antagonists & inhibitors Phorbols/pharmacology Tetradecanoylphorbol Acetate/pharmacology
Chemicals
Growth Inhibitors Insulin Mitogens Peptides Phorbols Fibroblast Growth Factors Epidermal Growth Factor Tetradecanoylphorbol Acetate
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Lechner J F
Kaighn M E
Article Info
Journal
Cell biology international reports
Abbr.
Cell Biol Int Rep
ISSN
0309-1651
Published
1980-01-00
Pages
23-8
Language
English
Region
England
NLM ID
7708050
Subset
IM
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