Moxalactam (LY127935), a new semisynthetic 1-oxa-beta-lactam antibiotic with remarkable antimicrobial activity: in vitro comparison with cefamandole and tobramycin.

Antimicrobial agents and chemotherapy ·Vol. 17 ·No. 4 ·1980-04-00 ·Pages 750-6

Jones RN, Fuchs PC, Sommers HM, Gavan TL, Barry AL, Gerlach EH

Abstract

Moxalactam (LY127935) exhibited greater in vitro activity than cefamandole and tobramycin against clinical isolates of Enterobacteriaceae, Aeromonas hydrophila, and Pseudomonas maltophilia. The activities of the three drugs against other microorganisms were as follows: for staphylococci, cefamandole = tobramycin greater than moxalactam; for streptococci, cefamandole greater than moxalactam greater than tobramycin; and for Pseudomonas aeruginosa, tobramycin greater than moxalactam greater than cefamandole. Moxalactam also demonstrated significant activity against the Bacteroides fragilis group and other anaerobes. Moxalactam was comparable to cefotaxime (HR756) in its inhibition of cephalothin-resistant and aminoglycoside-resistant clinical isolates.

MeSH Terms

Aminoglycosides/pharmacology Anti-Bacterial Agents/pharmacology Bacteria/drug effects Cefamandole/pharmacology Cephalosporins/pharmacology Cephamycins/pharmacology Drug Resistance, Microbial Enterobacteriaceae/drug effects Microbial Sensitivity Tests Moxalactam Pseudomonas aeruginosa/drug effects Staphylococcus/drug effects Streptococcus/drug effects Tobramycin/pharmacology

Chemicals

Aminoglycosides Anti-Bacterial Agents Cephalosporins Cephamycins Cefamandole Moxalactam Tobramycin

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Jones R N

Fuchs P C

Sommers H M

Gavan T L

Barry A L

Gerlach E H

References (16)

16 references, click to expand

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Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.17.4.750

Published

1980-04-00

Pages

750-6

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC283866

Subset

External Links

PubMed source DOI: 10.1128/AAC.17.4.750 PMC Full Text View journal details

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Moxalactam (LY127935), a new semisynthetic 1-oxa-beta-lactam antibiotic with remarkable antimicrobial activity: in vitro comparison with cefamandole and tobramycin.

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