Home LiteratureArticle Details
PMID: 6447113 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Cotransformation of a serum resistance phenotype with genes for arginine biosynthesis in Neisseria gonorrhoeae.

Infection and immunity ·Vol. 29 ·No. 1 ·1980-07-00 ·Pages 287-9

Spratt SK, Jones F, Shockley TE, Jackson JH

Abstract

Two genes (arg-3 and arp-6) marked by arginine auxotrophy and a gene (sac-2) marked by resistance to serum killing were found to be linked by cotransformation. Evidence derived from the linkage of these markers to spc (spectinomycin resistance) suggests that sac-2 may be genetically distinct from a sac gene previously described.

MeSH Terms
Arginine/biosynthesis Blood Bactericidal Activity Chromosome Mapping Chromosomes, Bacterial Drug Resistance, Microbial Escherichia coli/physiology Genes Genetic Linkage Neisseria gonorrhoeae/genetics Spectinomycin/pharmacology Transformation, Bacterial
Chemicals
Spectinomycin Arginine
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Spratt S K
Jones F
Shockley T E
Jackson J H
References (11)
11 references, click to expand
  1. Low antibiotic resistance of gonococci causing disseminated infection.
    N Engl J Med. 1973 Jun 7;288(23):1221-2 PMID: 4633690
  2. Nutritional profiles of Neisseria gonorrhoeae, Neisseria meningitidis, and Neisseria lactamica in chemically defined media and the use of growth requirements for gonococcal typing.
    J Infect Dis. 1973 Aug;128(2):178-94 PMID: 4198720
  3. Neisseria gonorrhoeae auxotyping: differentiation of clinical isolates based on growth responses on chemically defined media.
    Appl Microbiol. 1973 Sep;26(3):223-30 PMID: 4201637
  4. Development of a defined minimal medium for the growth of Neisseria gonorrhoeae.
    Appl Microbiol. 1974 Jul;28(1):70-6 PMID: 4210728
  5. Genetic mapping of linked antibiotic resistance loci in Neisseria gonorrhoeae.
    J Bacteriol. 1974 Dec;120(3):1284-92 PMID: 4279905
  6. Disseminated gonococcal infections caused by Neisseria gonorrhoeae with unique nutritional requirements.
    J Infect Dis. 1975 Aug;132(2):204-8 PMID: 125773
  7. Characteristics of atypical Neisseria gonorrhoeae from disseminated and localized infections.
    Infect Immun. 1976 May;13(5):1510-6 PMID: 818027
  8. Gonococci causing disseminated gonococcal infection are resistant to the bactericidal action of normal human sera.
    J Clin Invest. 1976 Nov;58(5):1163-73 PMID: 825532
  9. Penicillin sensitivity and serum resistance are independent attributes of strains of Neisseria gonorrhoeae causing disseminated gonococcal infection.
    Infect Immun. 1977 Mar;15(3):834-41 PMID: 404247
  10. Genetic studies on Neisseria gonorrhoeae from disseminated gonococcal infections.
    Infect Immun. 1977 Oct;18(1):165-72 PMID: 409684
  11. NEISSERIA GONORRHOEAE. I. VIRULENCE GENETICALLY LINKED TO CLONAL VARIATION.
    J Bacteriol. 1963 Jun;85:1274-9 PMID: 14047217
Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.29.1.287-289.1980
Published
1980-07-00
Pages
287-9
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC551111
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.29.1.287-289.1980 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2