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PMID: 6452591 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Histamine hyperpolarizes hippocampal neurones in vitro.

Neuroscience letters ·Vol. 22 ·No. 1 ·1981-02-23 ·Pages 75-8

Haas HL

Abstract

The postsynaptic effect of histamine and impromidine, an H2-receptor agonist on CA1 pyramidal and dentate granule cells in the hippocampal slice of the rat is a hyperpolarization. Depolarizations are indirectly mediated. It is suggested that the hyperpolarization is generated by a conductance increase to potassium ions in the dendrites.

MeSH Terms
Animals Electric Conductivity Guanidines/pharmacology Hippocampus/drug effects,physiology Histamine/pharmacology Imidazoles/pharmacology Impromidine Membrane Potentials/drug effects Neurons/drug effects,physiology Rats Receptors, Histamine H2/drug effects
Chemicals
Guanidines Imidazoles Receptors, Histamine H2 Histamine Impromidine
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Haas H L
Article Info
Journal
Neuroscience letters
Abbr.
Neurosci Lett
ISSN
0304-3940
DOI
10.1016/0304-3940(81)90288-3
Published
1981-02-23
Pages
75-8
Language
English
Region
Ireland
NLM ID
7600130
Subset
IM
External Links
PubMed source DOI: 10.1016/0304-3940(81)90288-3 View journal details
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