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PMID: 645361 Published · ppublish English Case Reports Journal Article

Electron microscopic structure of the Alzheimer's neurofibrillary changes in case of atypical senile dementia.

Acta neuropathologica ·Vol. 41 ·No. 3 ·1978-03-15 ·Pages 229-34

Shibayama H, Kitoh J

Abstract

A man aged 70, showed early disorientation, memory defects, delusions and rages at 66, later mental deterioration with muteness and dysphagia. He died of cardiac failure. The postmortem examination revealed macroscopically and light microscopically the neuropathological findings of atypical senile dementia. Moreover, it is the interesting characteristic in the presented case that there are electron microscopically two types of filaments making the neurofibrillary tangles. One showed the so-called "paired helical filaments", which were observed in the cerebral cortex. The other showed paralled "straight filaments". These "straight filaments" were found in the bilateral hippocampi.

MeSH Terms
Aged Autopsy Brain/ultrastructure Dementia/pathology Hippocampus/ultrastructure Humans Male Microscopy, Electron Neurofibrils/ultrastructure
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Shibayama H
Kitoh J
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35 references, click to expand
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Article Info
Journal
Acta neuropathologica
Abbr.
Acta Neuropathol
ISSN
0001-6322
DOI
10.1007/BF00690441
Published
1978-03-15
Pages
229-34
Language
English
Region
Germany
NLM ID
0412041
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00690441 View journal details
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