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PMID: 6456093 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Increased numbers of cells with suppressor T cell phenotype in the peripheral blood of patients with infectious mononucleosis.

Clinical and experimental immunology ·Vol. 43 ·No. 2 ·1981-02-00 ·Pages 291-7

Crawford DH, Brickell P, Tidman N, McConnell I, Hoffbrand AV, Janossy G

Abstract

Peripheral blood cells from six patients with acute infectious mononucleosis were studied by two-colour immunofluorescence using antibodies to human T cells, inducer and suppressor-cytotoxic T cell subsets and Ia-like antigens. The absolute number of T cells with the suppressor-cytotoxic phenotype was substantially increased in each case; many of these cells also expressed Ia-like antigens and had the morphology of the large atypical cells characteristic of infectious mononucleosis. These activated suppressor T cells of infectious mononucleosis may therefore represent a control mechanism to prevent viral-induced proliferation of B cells.

MeSH Terms
Cytotoxicity Tests, Immunologic Fluorescent Antibody Technique Histocompatibility Antigens Class II/analysis Humans Infectious Mononucleosis/immunology Leukocyte Count Phenotype T-Lymphocytes/immunology T-Lymphocytes, Regulatory/immunology
Chemicals
Histocompatibility Antigens Class II
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Crawford D H
Brickell P
Tidman N
McConnell I
Hoffbrand A V
Janossy G
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31 references, click to expand
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Article Info
Journal
Clinical and experimental immunology
Abbr.
Clin Exp Immunol
ISSN
0009-9104
Published
1981-02-00
Pages
291-7
Language
English
Region
England
NLM ID
0057202
PMCID
PMC1537280
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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