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PMID: 6456228 Published · ppublish English Comparative Study Journal Article

Vaginal isolates of Staphylococcus aureus associated with toxic shock syndrome.

Infection and immunity ·Vol. 33 ·No. 2 ·1981-08-00 ·Pages 442-9

Barbour AG

Abstract

Staphylococcus aureus has been isolated from vaginal fluids of women with toxic shock syndrome (TSS), a multisystem disease with onset usually during menses. A total of 15 vaginal isolates of S. aureus from TSS patients were compared with 18 vaginal isolates from women without TSS. Phenotypic traits which were significantly more frequent in the TSS group of strains than in the non-TSS group were arsenate resistance, proteolysis of hemoglobin, reduced hemolysis of sheep blood in agar medium, and lack of lethality of culture filtrates for chicken embryos and rabbits. In addition, isoelectric focusing of ethanol extracts of culture filtrates showed differences between the two groups in the occurrence of two proteins. All hemolytic and chicken embryo-lethal strains (3 TSS strains and 14 non-TSS strains) produced an extracellular protein with an isoelectric point of 8.6. In contrast, all TSS strains, but only one-half of non-TSS strains, released a protein with an isoelectric point of 7.0 and an apparent subunit molecular weight of 22,000.

MeSH Terms
Animals Anti-Bacterial Agents/pharmacology Bacterial Proteins/analysis Bacteriophage Typing Chick Embryo Female Hemolysis Humans Hydrolases/metabolism Metals/pharmacology Rabbits Shock, Septic/microbiology Staphylococcal Protein A/biosynthesis Staphylococcus Phages Staphylococcus aureus/pathogenicity,physiology Vagina/microbiology
Chemicals
Anti-Bacterial Agents Bacterial Proteins Metals Staphylococcal Protein A Hydrolases
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Barbour A G
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22 references, click to expand
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.33.2.442-449.1981
Published
1981-08-00
Pages
442-9
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC350717
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.33.2.442-449.1981 PMC Full Text View journal details
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