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PMID: 6456264 Published · ppublish English Journal Article

Characterization of 2-aminoisobutyric acid transport in Neurospora crassa: a general amino acid permease-specific substrate.

Journal of bacteriology ·Vol. 147 ·No. 3 ·1981-09-00 ·Pages 944-8

Ogilvie-Villa S, DeBusk RM, DeBusk AG

Abstract

We report the characterization of an amino acid 2-aminoisobutyric acid was transported solely by the general amino acid permease and not by the neutral amino acid permease. Furthermore, this substrate was not metabolized after transport. The potential for a system-specific nonmetabolizable substrate as a tool in the analysis of amino acid transport and its regulation is discussed.

MeSH Terms
Amino Acid Transport Systems Aminoisobutyric Acids/metabolism Biological Transport, Active Citrulline/metabolism Fungal Proteins/biosynthesis Kinetics Membrane Transport Proteins/metabolism Mutation Neurospora/metabolism Neurospora crassa/genetics,metabolism Substrate Specificity
Chemicals
Amino Acid Transport Systems Aminoisobutyric Acids Fungal Proteins Membrane Transport Proteins Citrulline
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Ogilvie-Villa S
DeBusk R M
DeBusk A G
References (10)
10 references, click to expand
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    Biochim Biophys Acta. 1965 Jun 15;104(1):139-50 PMID: 5840393
  2. Genetic control of amino acid permeability in Neurospora crassa.
    J Bacteriol. 1966 Feb;91(2):677-84 PMID: 5883112
  3. Genetic control of the uptake of amino acids in Neurospora.
    Genetics. 1966 Aug;54(2):677-85 PMID: 5968647
  4. Amino acid transport in Neurospora crassa. I. Properties of two amino acid transport systems.
    Biochim Biophys Acta. 1969 Jan 28;173(1):113-27 PMID: 4975665
  5. Regulation of amino acid assimilation in a strain of Neurospora crassa lacking basic amino acid transport activity.
    Biochim Biophys Acta. 1969 Dec 30;192(3):455-61 PMID: 5368248
  6. Developmental regulation of amino acid transport in Neurospora crassa.
    J Bacteriol. 1970 Nov;104(2):689-97 PMID: 5489433
  7. Molecular transport. I. In vivo studies of transport mutants of Neurospora crassa with altered amino acid competition patterns.
    Arch Biochem Biophys. 1971 Jun;144(2):503-11 PMID: 5569897
  8. Transport of -aminoisobutyric acid in Saccharomyces cerevisiae.
    Biochim Biophys Acta. 1972 Nov 2;288(2):380-9 PMID: 4563235
  9. Isolation and characterization of a mutant of Neurospora crassa deficient in general amino acid permease activity.
    Biochim Biophys Acta. 1975 Nov 17;413(1):45-51 PMID: 127619
  10. Physiological and regulatory properties of the general amino acid transport system of Neurospora crassa.
    J Bacteriol. 1980 Jul;143(1):188-97 PMID: 6447141
Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.147.3.944-948.1981
Published
1981-09-00
Pages
944-8
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC216132
Subset
IM
External Links
PubMed source DOI: 10.1128/jb.147.3.944-948.1981 PMC Full Text View journal details
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