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PMID: 6457058 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The effects of thyroid status on some properties of rat fast-twitch muscle.

Journal of muscle research and cell motility ·Vol. 2 ·No. 3 ·1981-09-00 ·Pages 307-20

Nwoye L, Mommaerts WF

Abstract

The effects of different thyroid states on some histochemical and biochemical properties of fast-twitch muscle were studied using rat extensor digitorum longus (EDL) muscle. This muscle was found to be much less responsive to thyroidal influence than the slow-twitch soleus muscle. In EDL muscles of hypothyroid rats, fast leads to slow conversions were observed in fibre type composition, myosin ATPase activity and light chain pattern, and in the subunit composition of lactate dehydrogenase, while the only significant slow leads to fast conversion observed in thyrotoxicosis was a decrease in the proportion of slow-oxidative fibres. Denervation of the hypothyroid muscle produced the highest degree of fast leads to slow transformation. These findings support the view that denervation and dysthyreosis alter gene expression in muscle by independent mechanisms.

MeSH Terms
Adenosine Triphosphatases/metabolism Animals Histocytochemistry Hyperthyroidism/chemically induced,physiopathology L-Lactate Dehydrogenase/metabolism Male Muscle Denervation Muscles/physiology Myosins/metabolism Rats Rats, Inbred Strains Thyroidectomy Thyroxine/blood Triiodothyronine/blood
Chemicals
Triiodothyronine L-Lactate Dehydrogenase Adenosine Triphosphatases Myosins Thyroxine
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Nwoye L
Mommaerts W F
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34 references, click to expand
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Article Info
Journal
Journal of muscle research and cell motility
Abbr.
J Muscle Res Cell Motil
ISSN
0142-4319
DOI
10.1007/BF00713269
Published
1981-09-00
Pages
307-20
Language
English
Region
Netherlands
NLM ID
8006298
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00713269 View journal details
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