On the statistical assessment of similarities in DNA sequences.

Nucleic acids research ·Vol. 12 ·No. 13 ·1984-07-11 ·Pages 5529-43

Reich JG, Drabsch H, Däumler A

Abstract

The statistical behavior of the similarity score for unrelated DNA sequences calculated as letter-by-letter comparison or from various forms of optimal alignment was studied. It was found that natural DNA-sequences from a data base and true random sequences show the same statistical behavior in terms of such scores. This makes it possible to adopt a simple criterion for the rejection of fortuitous similarity. It is based on the mean and standard deviation of chance scores whose expected values, depending on chain length, gap penalty and probability of letter coincidence, may be calculated from formulae given in the paper.

MeSH Terms

Base Sequence DNA/genetics Models, Genetic Probability Statistics as Topic

Chemicals

DNA

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Reich J G

Drabsch H

Däumler A

References (9)

9 references, click to expand

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Article Info

Journal

Nucleic acids research

Abbr.

Nucleic Acids Res

ISSN

0305-1048

DOI

10.1093/nar/12.13.5529

Published

1984-07-11

Pages

5529-43

Language

English

Region

England

NLM ID

0411011

PMCID

PMC318937

Subset

External Links

PubMed source DOI: 10.1093/nar/12.13.5529 PMC Full Text View journal details

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On the statistical assessment of similarities in DNA sequences.

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