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PMID: 646819 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Kinetics of tetrahydrobiopterin synthesis by rabbit brain dihydrofolate reductase.

The Biochemical journal ·Vol. 171 ·No. 1 ·1978-04-01 ·Pages 267-8

Abelson HT, Spector R, Gorka C, Fosburg M

Abstract

Product identification and kinetic data are presented for the conversion of 7,8-dihydrobiopterin into tetrahydrobiopterin by purified rabbit brain dihydrofolate reductase.

MeSH Terms
Animals Biopterin/analogs & derivatives,biosynthesis Brain/enzymology Kinetics Phenylalanine Hydroxylase/metabolism Pteridines/biosynthesis Rabbits Tetrahydrofolate Dehydrogenase/metabolism
Chemicals
Pteridines Biopterin Phenylalanine Hydroxylase Tetrahydrofolate Dehydrogenase sapropterin
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Abelson H T
Spector R
Gorka C
Fosburg M
References (6)
6 references, click to expand
  1. Enzymatic synthesis of biopterin from D-erythrodihydroneopterin triphosphate by extracts of kidneys from Syrian golden hamsters.
    J Biol Chem. 1976 Nov 10;251(21):6505-12 PMID: 10299
  2. Identification of dihydrofolate reductase in rabbit brain.
    Biochem Pharmacol. 1977 Aug 15;26(16):1507-11 PMID: 901568
  3. Partial purification and characterization of tryptophan hydroxylase from rabbit hindbrain.
    J Biol Chem. 1972 Jul 10;247(13):4165-73 PMID: 4402511
  4. Metabolism of the phenylalanine hydroxylation cofactor.
    J Biol Chem. 1967 Sep 10;242(17):3934-43 PMID: 4382563
  5. p-Chlorphenylalanine effect on phenylalanine hydroxylase in hepatoma cells in culture.
    J Biol Chem. 1975 Feb 10;250(3):1132-40 PMID: 234440
  6. Purification and some physical properties of phenylalanine hydroxylase from rat liver.
    J Biol Chem. 1970 Sep 25;245(18):4745-50 PMID: 5456147
Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj1710267
Published
1978-04-01
Pages
267-8
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1184156
Subset
IM
External Links
PubMed source DOI: 10.1042/bj1710267 PMC Full Text View journal details
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