Human chromosome hot points. 1. Hot point at 3p14 in three populations.

Human genetics ·Vol. 67 ·No. 3 ·1984-00-00 ·Pages 249-51

Zhou XT, Xu BH, Chu CL, Xia GF, Li N, Sha R

Abstract

A chromosome hot point, 3p14, in healthy peasants, mentally retarded patients (MR), and epileptic patients (EP) was studied. The frequency of the hot point, 3p14 break, was significantly higher in EP. It may be caused by folic acid reduction in patients' serum induced by the antiepileptic drugs. The difference between hot point and fragile site is discussed.

MeSH Terms

Adolescent Adult Anticonvulsants/pharmacology Child Child, Preschool Chromosome Aberrations Chromosome Mapping Chromosomes, Human, 1-3 Epilepsy/genetics Female Humans Infant Intellectual Disability/genetics Male Middle Aged

Chemicals

Anticonvulsants

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Zhou X T

Xu B H

Chu C L

Xia G F

Li N

Sha R

References (11)

11 references, click to expand

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Folic acid and anticonvulsants.
Lancet. 1968 May 4;1(7549):980 PMID: 4171606
A new inducible fragile site on chromosome 3(p14.2) in human lymphocytes.
Hum Genet. 1983;63(3):297-8 PMID: 6852828
5-Fluoro-2'-deoxyuridine induction of the fragile site on Xq28 associated with X linked mental retardation.
J Med Genet. 1981 Oct;18(5):374-6 PMID: 6460104
Folic acid and neuropathy in epilepsy.
Lancet. 1968 Jan 20;1(7534):146 PMID: 4169634
Chromosome abnormalities in lymphocytes from normal human subjects. A study of 3,720 cells.
Cytogenetics. 1967;6(6):402-11 PMID: 5587548
Methotrexate-induced increase in gap formation in human chromosome band 3p14.
Hereditas. 1982;96(2):317-9 PMID: 6985468
A new heritable fragile site on human chromosome 3.
Hereditas. 1983;98(2):297-9 PMID: 6874402
Anticonvulsant therapy, folic acid and vitamin B12 metabolism and mental symptoms.
Epilepsia. 1966 Dec;7(4):261-70 PMID: 5227261
Relationships between serum and cerebrospinal fluid anticonvulsant drug and folic acid concentrations in epileptic patients.
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Article Info

Journal

Human genetics

Abbr.

Hum Genet

ISSN

0340-6717

DOI

10.1007/BF00291350

Published

1984-00-00

Pages

249-51

Language

English

Region

Germany

NLM ID

7613873

Subset

External Links

PubMed source DOI: 10.1007/BF00291350 View journal details

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Human chromosome hot points. 1. Hot point at 3p14 in three populations.

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